氨甲环酸治疗黄褐斑的研究进展  

Research progress of tranexamic acid in treatment of chloasma

作　　者：李健和[1] 胡焰[2] 赵子影[2] 刘新义[1] 彭六保[1] 易利丹[1] 

机构地区：[1]中南大学湘雅二医院药学部,湖南长沙410011 [2]中南大学药学院,湖南长沙410013

出　　处：《中国新药与临床杂志》2013年第6期440-443,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：越来越多的临床研究表明,口服和(或)局部给予氨甲环酸治疗黄褐斑疗效良好,不良反应小,可单独或联合其他药物或方法进行治疗。其作用机制与酪氨酸酶相关,可能直接与酪氨酸竞争,干扰酪氨酸酶对酪氨酸代谢的催化作用;也可能通过抑制纤溶酶原-纤溶酶系统干扰黑色素细胞和角化细胞的相互作用,降低酪氨酸酶的活性,从而抑制黑色素细胞黑色素的合成。More and more clinical studies have shown that oral and （or） local administration of tranexamic acid as either monotherapy or adjunctive therapy is effective and safe for chloasma patients. The mechanism of its action is related with tyrosinase. It may interfere with the catalysis of tyrosinase by producing competition with tyrosine directly or may inhibit melanin synthesis in melanocytes by interfering with the interaction of melanocytes and keratinocytes for reducing the activity of tyrosinase through inhibition of the plasminogen/plasmin system.

关 键 词：氨甲环酸 黄褐斑 药物疗法 

分 类 号：R986[医药卫生—药品]