咪唑斯汀联合防风通圣颗粒治疗老年性瘙痒症的疗效观察  

Effects of Fangfengtongsheng granule and mizolastine on pruritus in elderly patients

作　　者：曾韬[1] 宁苏莉 何春梅 

机构地区：[1]上海市徐汇区康健街道社区卫生服务中心,上海200233 [2]上海市第八人民医院皮肤科,上海200235 [3]烟台渤海制药集团有限公司,山东烟台264000

出　　处：《广州医学院学报》2013年第2期90-92,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨咪唑斯汀联合防风通圣颗粒治疗老年性瘙痒症的临床疗效。方法:96例老年瘙痒症患者被随机分为3组:治疗组(36例)口服咪唑斯汀联合防风通圣颗粒,对照A组(30例)口服咪唑斯汀,对照B组(30例)口服防风通圣颗粒,每组各32例。结果:治疗14 d时,治疗组与对照B组有效率比较,差异有统计学意义(P<0.05)。治疗28 d时,治疗组与对照A组、对照B组有效率比较,差异有统计学意义(P<0.05)。治疗组轻度腹泻1例;对照A组乏力、困倦2例;对照B组未见明显不良反应。结论:咪唑斯汀联合防风通圣颗粒治疗老年人瘙痒症疗效较为满意,不良反应轻微,值得临床推广。Objective：To investigate the efficacy of Fangfengtongsheng granule and mizolastine on pruritus in elderly patients. Methods ： Ninety-six elderly patients with pruritus were randomly assigned to be treated with mizolastine （group A, n = 30） or Fangfengtongsheng granule alone （group B, n = 30）, or in combination （group C, n = 36）, respectively. Results： There was a substantial difference in the rate of effectiveness between group B and group C （P 〈 0.05 ） at day 14. The among-group difference in the rate of effectiveness was remarkable at day 28 （P 〈0.05）. Group A was associated with 2 cases of fatigue and malaise and group C had a single case of mild diarrhea. No significant adverse event was reported in group B. Conclusion： The combination of Fangfengtongsheng granule and mizolastine achieves a preferable efficacy yet mild adverse events in elderly patients with pruritus and deserves clinical promotion.

关 键 词：咪唑斯汀 防风通圣颗粒 瘙痒症 老年人 

分 类 号：R758.31[医药卫生—皮肤病学与性病学]