羧胺三唑对角叉菜胶诱导急性炎症的抗炎作用  

Anti-inflammatory effects of carboxyamidotriazole on carrageenan-induced acute inflammation

作　　者：朱蕾[1,2] 李娟[1,2] 武丹威[1,2] 于晓丽[1,2] 郭磊[1,2] 叶菜英[1,2] 张德昌[1,2] 

机构地区：[1]中国医学科学院,基础医学研究所 [2]北京协和医学院基础学院药理系,北京100005

出　　处：《中国临床药理学与治疗学》2013年第6期601-606,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(81102454;30873075);"重大新药创制"科技重大专项(2009ZX09102-049);中国医学科学院院所长基金(2010PY01;2010PY08)

摘　　要：目的:探讨羧胺三唑(CAI)对角叉菜胶诱导的大鼠足爪急性炎症的预防作用及部分机制。方法:采用角叉菜胶诱导大鼠足爪急性炎症模型,测量足爪肿胀度以及足爪组织中髓过氧化物酶(MPO)、NO、前列腺素2(PGE2)、TNF-α、IL-1β、中性粒细胞趋化因子-1(CNCI-1)和诱导一氧化氮合酶(iNOS)。结果:CAI能明显减轻大鼠足爪炎性肿胀,显著降低炎症足爪中MPO、NO、PGE2、TNF-α、IL-1β和CNCI-1含量及iNOS蛋白表达。结论:CAI可能通过减少炎症介质和中性粒细胞浸润来发挥对角叉菜胶诱导急性炎症的抗炎作用。AIM： To investigate the preventive effects of carboxyamidotriazole （CAI） in rat model of carrageenan-induced paw acute inflammation and its mechanisms. METHODS： The paw acute inflammation in rats was induced by carrageenan. The paw swelling was measured, and myeloperoxidase （MPO）, NO, PGE2, TNF-α, IL-1β, cytokine-induced neutrophil chemoattractant-1 （CNCI-1） and iNOS in the paw tissues were determined. RESULTS： CAI attenuated the carrageenan-induced paw swelling. And CAI decreased the contents of MPO, NO, PGE2, TNF-α, IL-1β and CNCI-1 in the inflamed paw tissues. Also, the protein expression of iNOS was reduced by CAI. CONCLUSION： CAI has anti-inflammatory effects against carrageenan-induced acute inflammation by decreasing the inflammatory mediators and the neutrophils infiltration.

关 键 词：羧胺三唑 急性炎症 角叉菜胶 髓过氧化物酶 炎症介质 

分 类 号：R965.2[医药卫生—药理学]