JNK信号通路与细胞凋亡关系的研究进展  

Research development between JNK pathway and apoptosis

作　　者：魏娜[1] 贺海波[2] 张长城[1] 袁丁[1] 王婷[1] 

机构地区：[1]三峡大学医学院 [2]天然产物研究与利用湖北省重点实验室(三峡大学)

出　　处：《中国临床药理学与治疗学》2013年第7期807-812,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金资助项目(81273895;31070314;30873383)

摘　　要：c-Jun氨基末端激酶(c-Jun N-terminal ki-nase,JNK)信号通路是近20年来发现的与细胞分化、细胞凋亡、应激反应以及多种人类疾病的发生和发展关系非常密切的通路之一,其生物化学功能和对细胞生理、病理情况下的调节作用一直被国内外学者所关注。近年来,研究发现JNK信号通路在调控细胞凋亡中发挥重要作用,通过调节JNK信号通路有望成为治疗细胞凋亡引起的疾病的重要靶点。本文就其生物学功能及其与细胞凋亡关系作一阐述。JNK pathway is closely associated with cell differentiation, apoptosis, stress response and many hunman diseases in the past 20 years, whose biochemical function, regulation under cell physiology and pathology are constantly noticed by domestic and foreign scholars. Recently, more research suggests that it plays an important role in regulating apoptosis, and it will be an important potential target for treatment of apoptosis-associated disease by regulating JNK signal pathway. In summary, the physiological and pathophysiological functions of JNK pathway and relation with apoptosis have been reviewed.

关 键 词：JNK信号通路 细胞凋亡 丝裂原活化蛋白激酶 

分 类 号：R965.2[医药卫生—药理学]