内皮微颗粒与心血管疾病的临床评估  

Endothelial Microparticles and Clinical Assessment of Cardiovascular Diseases

作　　者：崔丽[1] 李莹[1] 李纪明[1] 

机构地区：[1]同济大学附属东方医院心内科,上海市200120

出　　处：《中国动脉硬化杂志》2013年第6期557-561,共5页Chinese Journal of Arteriosclerosis

基　　金：上海市科委攻关项目(10411968000);上海市自然科学基金(10ZR1406600);辉瑞制药有限公司研究者发起基金项目(WS1788785)

摘　　要：内皮微颗粒是从激活或者凋亡的内皮细胞表面脱落的无核囊泡样结构,通过表面蛋白分子介导体内生物过程中的信息传导,其释放受到体内多种因素的精密调节,在心血管疾病发生发展过程中起着重要的作用。本文将对内皮微颗粒的结构、功能及其与心血管疾病的关联,尤其是内皮微颗粒在心血管疾病风险评估、监测和治疗中的临床意义,并结合目前研究进展做一综述。Endothelial microparticles are the vesicles without nucleus shed from the plasma membranes of endothelial cells that are activated or undergoing apoptosis, which is involved in many signal transduction in vivo. The action of endothelial microparticles detaching from the endothelial cell is regulated precisely by a variety factors in vivo, and which play a key role in the occurrence and development of cardiovascular diseases. In this paper the structure, function of the endothelial microparticles and their association with cardiovascular diseases, especially the clinical significance of endothelial microparticles in cardiovascular diseases risk assessment, monitoring and treatment, combined with the current research progress are reviewed.

关 键 词：内皮微颗粒 内皮功能 心血管疾病 临床评估 

分 类 号：R5[医药卫生—内科学]