白芍总苷联合吡美莫司治疗散发型白癜风的临床疗效及相关实验研究  

Clinical Effect and Relevant Experimental Study in Patients with Sporadic Vitiligo by the Combination of Total Glucosides of Paeony and Pimecrolimus

作　　者：叶蓉[1] 聂李平[1] 胡小平[1] 黄星涛[1] 江晓君[1] 

机构地区：[1]北京大学深圳医院,深圳518036

出　　处：《中国中西医结合皮肤性病学杂志》2013年第3期155-157,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：深圳市科技计划课题项目阶段性成果(编号:201102013)

摘　　要：目的评价白芍总苷联合吡美莫司对散发型白癜风患者的治疗效果。方法 45例患者根据病程分3组:<6个月组、6个月～2年组及≥2年组,均给予白芍总苷联合吡美莫司软膏治疗,用流式细胞仪对3组患者治疗前后外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平进行检测,同时评价皮损恢复情况。结果与治疗前相比,治疗后3组散发型白癜风患者皮损均有不同程度的恢复,外周血中CD4+/CD8+T细胞比值和CD4+CD25+调节性T细胞水平均升高(P<0.05),且<6个月组明显高于另2组,差异有统计学意义(P<0.05)。结论白芍总苷联合吡美莫司能促进散发型白癜风患者皮损恢复,改善外周血CD4+/CD8+T细胞比值,提高CD4+CD25+调节性T细胞水平。Objective To investigate treatment effect in patients with sporadic vitiligo by the combination of total glucosides of paeony （TGP） and pimecrolimus. Methods According to the course of disease, 45 patients were divided into three groups： less than six months, between six months and two years, more than two years. All groups were treated with the combination of TGP and pimecrolimus. The CD4＋/CD8＋ T lymphocyte ratio and the CD4＋CD25＋ Treg level in patients of the three groups, before and after treatment, were detected by flow cytometry. Meanwhile, the skin lesion recovery was evaluated. Results In the same group, the lesions in patients had different degree of recovery after treatment, the CD4＋/CD8＋ T lymphocyte ratio and the CD4＋CD25＋ Treg level increased after treatment （P〈0.05）. The group which course of disease was less than six months, increased significantly （P〈0.05）. Conclusion TGP combined with pimecrolimus could promote the recovery of skin lesions in patients with sporadic vitiligo, improve the CD4＋/CD8＋T lymphocyte ratio and the CD4＋CD25＋ Treg level in peripheral blood.

关 键 词：白癜风 散发型 白芍总苷 吡美莫司 T细胞 调节性 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]