ACE基因缺失多态性与中国人妊娠高血压综合征发病易感性的Meta分析  

Meta analysis of correlation of angiotensin-converting enzyme gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension in Chinese women

作　　者：李战战[1] 陈立章[1] 刘立亚[1] 薛静[1] 杨洋[1] 胡莹云[1] 

机构地区：[1]中南大学公共卫生学院流行病与卫生统计学系,长沙410078

出　　处：《中南大学学报（医学版）》2013年第6期631-638,共8页Journal of Central South University ：Medical Science

摘　　要：目的:探讨中国人群中血管紧张素转化酶(angiotensin-converting enzyme,ACE)基因缺失多态性与妊娠高血压综合征发病的相关性。方法:利用网络数据库检索中国知网、万方、VIP和PubMed,检索时间从建库至2012年3月,收集有关ACE基因缺失多态性与中国人群妊娠高血压综合征发病关系的病例-对照研究。在评价纳入文献质量,提取有效数据后,采用Stata11.0软件进行Meta分析。结果:共纳入11篇病例-对照研究,含806个病例,900个对照,Meta分析显示各基因型合并后的OR值与95%CI,其中D等位基因vs I等位基因:OR=2.73,95%CI(1.64,4.24);基因型DD+DI vs基因型II:OR=3.11,95%CI(1.98,4.90);基因型DD vs基因型II:OR=5.00,95%CI(2.30,10.88);基因型DI vs II基因型II:OR=1.97,95%CI(1.53,2.53),差异均有统计学意义(P<0.001)。结论:中国人中携带ACE基因缺失多态性D等位基因型个体妊娠高血压综合征的发病风险升高。Objective： To investigate the association of the polymorphism of angiotensin-converting enzyme （ACE） gene and pregnancy-induced hypertension （PIH） in Chinese Women. Methods： We systematically searched CNKI, Wanfang database, VIP and PubMed from database construction to March 2012 to collect case-control studies. Stata 11.0 was used for meta analysis after evaluating the quality of studies and collecting the data. The association was assessed by odds ratio （OR） with 95% confidence intervals （CIs）. Publication bias was analyzed by Begg＇s funnel plot and Egger＇s regression test. Results： We identified 11 case-control studies on association between ACE gene polymorphism and PIH, which included 806 PIH patients and 900 controls. Overall, significant association was found between ACE gene polymorphism and PIH risk [for D vs I： OR-2.73, 95% CI （1.64, 4.24）, P〈0.001; for DD＋DI vs II. OR=3.11, 95% CI （1.98, 4.90）, P〈0.001; for DD vs II： OR=5.00, 95% CI （2.30,10.88）, P〈0.001; for DI vs II： OR=1.97, 95% CI（1.53, 2.53）, P〈0.001]. Conclusion： Chinese women with D allele gene deletion have a higher risk of suffering pregnancy- induced hypertension syndrome.

关 键 词：血管紧张素转化酶 妊娠高血压综合征 基因多态性 META分析 

分 类 号：R714.246[医药卫生—妇产科学]