地黄饮子对血管性痴呆大鼠学习记忆能力的影响  

Effects of Rehmanniae Decoction on Learning and Memory Ability of Vascular Dementia Rats

作　　者：吴颂 谢宁[2] 窦金金[2] 关慧波[2] 袁晓霞[3] 

机构地区：[1]秦皇岛市中医院,河北秦皇岛066000 [2]黑龙江中医药大学,黑龙江哈尔滨150040 [3]新疆医科大学中医学院,新疆乌鲁木齐830054

出　　处：《贵阳医学院学报》2013年第3期251-252,256,共3页Journal of Guiyang Medical College

基　　金：国家自然科学基金项目(81102555)

摘　　要：目的:研究地黄饮子对血管性痴呆(vascular Dementia,VD)大鼠学习记忆能力的影响。方法:用改良后2-VO+硝普钠降压法制作VD大鼠模型,分为空白组、模型组、安理申对照组及地黄饮子组共4组,测试各组大鼠定位航行路经长度、穿越平台次数及逃避潜伏期。结果:经灌胃治疗4周后,地黄饮子组大鼠路径明显延长、60 s内穿越平台次数显著增加、60 s内首次穿越原平台时间显著缩短,与模型组大鼠相比差异有统计学意义(P<0.01),与安理申组相比无差异。结论:地黄饮子对VD模型大鼠的学习记忆能力有改善作用。Objective： To investigate the effects of rehmanniae decoction on learning and memory a- bility of vascular dementia （VD） rats, and to explore the mechanisms. Methods： VD rat model was established with modified 2-vessel occlusion method （2-VO） and sodium nitroprusside （SNP） depres- surization method. Wistar rats were randomly divided into normal group, model group, donepezil group and rehmanniae decoction group. Place navigation test and space exploration test were carried out in Morris water maze to detect learning and memory ability of rats. Results： After lavage treatment for 4 weeks, in rehmanniae decoction group, the path prolonged, the frequency of crossing platform in 60 seconds significantly increased, and latency for rats crossing platform for the first time in 60 seconds significantly shortened. Compared with the model grout）, the differences were significant（ P 〈0.01 ）, and compared with donepezil group, no significant difference was found. Conclusions： Rehmanniae decoction could improve learning and memory ability of VD rats.

关 键 词：痴呆 血管性 地黄饮子 迷宫学习 记忆 模型 动物 大鼠 WISTER 

分 类 号：R282.71[医药卫生—中药学] R363.21[医药卫生—中医学]