α-硫辛酸联合依帕司他治疗糖尿病神经病变临床观察  

Clinical observation of α-lipoic acid combined with epalrestat in the treatment of diabetic peripheral neuropathy

作　　者：罗方[1] 胡江平 李清楚[1] 

机构地区：[1]郑州市中心医院内分泌科,450007 [2]郑州市中医院

出　　处：《中国实用医刊》2013年第14期61-62,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察α-硫辛酸联合依帕司他治疗糖尿病周围神经病变的疗效。方法80例糖尿病周围神经病变患者随机分为两组各40例，对照组应用依帕司他，每次50mg，3次／d；治疗组在给予依帕司他治疗基础上，静脉给予α-硫辛酸600mg，1次／d。两组均以2周为1个疗程，观察治疗前后患者的临床症状及肌电图改善情况。结果两组治疗后正中神经和腓总神经的运动神经传导速度（MCV）和感觉神经传导速度（SCV）较治疗前均有明显改善（P〈0．05），治疗组较对照组改善更为明显，且差异有统计学意义（P〈0．05）。治疗组总有效率为87．5％，对照组为57．5％，二者比较差异有统计学意义（P〈0．01）。结论α-硫辛酸联合依帕司他可显著改善糖尿病周围神经病变症状，疗效优于单用依帕司他。Objective To observe the effect of α-lipoic acid（ALA） combined with epalrestat on diabetic peripheral neuropathy （DPN）. Methods Eighty DPN patients were randomly divided into experimental group（40 cases） and control group （40 cases）. Patients in control group received epalrestat50 mg oral taken, 3 times a day, and patients in experimental group were additionally given ALA 0. 6 g by inrtavenous drip infusion once a day. Both treatment lasted for 2 weeks. The clinical symptoms and nerve conduction velocity were compared before and after treatment. Results The nerve conduction velocity was obviously increased in both groups after 2 weeks treatment （ P 〈 0.05 ） , and the increase ment in experiment group was significantly higher than that in control group （ P 〈 0. 05）. Total effective rate of experimental group was 87.5%, and 57.5% in the control group, the difference had statistical significance（ P 〈 0.01 ）. Conclusions ALA combined with epalrestat can significantly improve the symptoms and the effect is better than the single use of epalrestat.

关 键 词：糖尿病周围神经病变 Oα一硫辛酸 依帕司他 

分 类 号：R587.2[医药卫生—内分泌]