癫痫患者默认网络的静息态功能磁共振成像研究  

A Resting-state Functional Magnetic Resonance Imaging Analysis of Default Mode Network in Epileptics

作　　者：张喆[1] 柯铭[1] 刘光耀[2] 杨晓萍[2] 陈旭辉[3] 

机构地区：[1]兰州理工大学计算机与通信学院,兰州730050 [2]兰州军区总医院影像诊断中心,兰州730000 [3]厦门理工学院福建省高校物联网应用重点实验室,厦门361024

出　　处：《中国临床心理学杂志》2013年第3期363-367,共5页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金项目(61065007,61263047);甘肃省自然科学基金(0916RJZA020);兰州理工大学博士基金项目(BS14200901)

摘　　要：目的:分析癫痫患者静息态fMRI下默认网络及其潜在结构的变化。方法:对15名临床诊断为原发全身强直痉挛癫痫患者和20名正常志愿者静息态时的fMRI数据进行独立成分分析,依据空间最佳匹配原则挑选独立成分,研究正常被试和癫痫患者的默认网络差异,并选定默认网络中11个脑区构建功能连接网络,运用图论和聚类方法探讨其潜在结构的改变。结果:与正常对照组相比,患者组默认网络的脑区激活普遍下降,功能连接网络发生明显变化,且整个网络呈现出混乱的层次化结构。结论:静息态下癫痫患者的默认网络及潜在的层次化结构发生异常。Objective： To analyze the default mode network （DMN） and its latent structure of epileptics in resting-state functional magnetic resonance imaging （fMRI）. Methods： The resting-state fMRI data of 15 clinically primary epileptics and 20 normal volunteers were analyzed by independent component analysis. We selected independent component accord- ing to the best-sit criterion and analyzed the DMN network of grouping sufferers and normal samples. Finally, we con- strueted a functional connecting network from the chosen 1 i encephalic regions in DMN with graph theory and clustering methods. Results： The encephalic region in DMN of sufferers dramatically fell and their functional connectivity network had obvious change along with the whole network presenting disordered hierarchical structure. Conclusion： The DMN and its latent hierarchical structure of epileptics in resting-state present disordered.

关 键 词：癫痫 静息态 默认网络 功能连接 层次化结构 

分 类 号：R395.1[哲学宗教—心理学]