代谢综合征痰湿证血清胰岛素、血尿酸、脂联素代谢特征研究  

Metabolic Characteristic Research of Serum Insulin,Blood Uric Acid and Adiponectin in Phlegm-Damp Pattern of Metabolic Syndrome

作　　者：董静[1] 马建伟[1] 魏汉林[1] 张文龙[1] 支艳[1] 

机构地区：[1]空军总医院,北京100142

出　　处：《世界中西医结合杂志》2013年第2期147-149,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：首都医学发展基金资助项目(SF-2009-I-13)

摘　　要：目的进行代谢综合征痰湿证与正常对照组血清胰岛素、血尿酸(UA)、脂联素水平比较。方法在临床流行病学调查的基础上,按代谢综合征痰湿证和正常对照组的诊断标准筛选代谢综合征痰湿证60例和正常对照组50例,上午8～9点空腹抽取静脉血,用自动生化仪检测空腹血糖、血尿酸;采用酶联免疫法(ELISA)检测空腹胰岛素(FINS)、脂联素,计算胰岛素敏感性指数(IAI)、稳态模型的胰岛素抵抗指数(HOMA-IR),并对代谢综合征痰湿证和正常对照组上述指标之间的差异进行分析。结果代谢综合征痰湿证空腹胰岛素水平显著高于正常对照组(P<0.05);UA显著高于正常对照组(P<0.01),代谢综合征痰湿证和正常对照组比较,IAI、HOMA-IR差异均有统计学意义(P<0.01),脂联素水平显著低于正常对照组(P<0.01)。结论代谢综合征痰湿证在胰岛素、UA、脂联素代谢方面具有特征。Objective To compare the levels of serum insulin, uric acid and adiponectin between phlegm - damp pattern of metabolic syndrome and the normal control group. Methods Based on the clinical epidemiological investigation, in terms of the diagnostic criteria of phlegm - damp pattern of metabolic syndrome and the normal control group ,60 cases of phlegm -damp pattern of metabolic syndrome and 50 eases in the normal control group were screened. The venous blood was collected in fasting,8am -9am. The auto- matic biochemical analyzer was used to detect fasting glucose blood and uric acid. The enzyme - linked immunosorbnent assay（ELISA）was adopted to detect the levels of fasting insulin and adiponectin. The insulin sensitivity index（IAI） and the homeostasis model assessment for insulin resistance（ HOMA -IR） were calculated. The differences in the above indexes were analyzed in phlegm - damp pattern of metabolic syndrome and the normal control group. Results The fasting insulin level of phlegm - damp pattern of metabolic syn- drome was higher significantly than that in the control group（ P 〈 0.05 ）and the level of uric acid was higher significantly than the normal control group（ P 〈 O. O1 ）. In comparison between phlegm - damp pattern of metabolic syndrome and the normal control group, the differences in IAI and HOMA - IR were significant statisti- cally（ P 〈 O. 01 ）. The level of adiponeetin was lower significantly than that in the normal control group（ P 〈 0. Ol ）. Conclusion Phlegm - damp pattern of metabolic syndrome presents its own specific characteristics in terms of insulin, uric acid and adiponectin.

关 键 词：代谢综合征 痰湿证 胰岛素 血尿酸 脂联素 

分 类 号：R589[医药卫生—内分泌]