血清降钙素原水平改变在COPD急性加重期患者感染及预后的临床意义分析  

The clinical significance of level changes of serum procalcitonin on the infection and prognosis in the patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：唐讯波 冯佩仪 

机构地区：[1]佛山市順德区龙江医院,528318

出　　处：《中国现代药物应用》2013年第13期23-24,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨血清降钙素原水平改变对COPD急性加重期患者感染及预后的临床意义。方法选择本院2010年2月至2013年2月慢性阻塞性肺疾病急性加重期患者共50例,其中非感染患者共14例、局部感染患者共26例、败血症或者脓毒血症患者共10例。检测所选患者血清降钙素原水平。结果非感染患者血清降钙素原水平为为(0.066±0.011)ng/ml,局部感染患者血清降钙素原水平为(0.451±0.147)ng/ml,败血症及脓毒症患者血清降钙素原水平为(2.841±0.873)ng/ml。脓毒血症及败血症患者的血清降钙素原水平高于局部感染患者,差异有统计学意义(P<0.05);局部感染患者血清降钙素原水平高于非感染患者,差异有统计学意义(P<0.05)。结论血清降钙素原水平改变有助于了解慢性阻塞性肺疾病急性加重期患者感染情况,有助于判断其预后。Objective To explore the clinical significance of level changes of Serum procalcitonin on the infection and prognosis in the patients with acute exacerbation of chronic obstructive pulmonary disease. Methods 50 cases with acute exacerbation of chronic obstructive pulmonary disease were selected from Febru ary,2010 to February , 2013 , non infected patients was 14 cases, 26 cases was local infection, sepsis or septic patients was 10 cases, the serum procalcitonin level was detected. Results The level of serum procalcitonin in the non infected patients was （0. 066 ±0. 011 ） ng/ml, the level of serum proealcitonin in the patients with lo cal infection was （0. 453 ±0. 147） ng/ml,the level of serum procalcitonin in the patients with sepsis or septicwas （2. 841± 0. 873 ） ng/ml. The level of serum procalcitonin in the patients with sepsis and septic was high er than that in the patients with local infection, the difference was statistically significant （P 〈 0. 05 ） ; the level of serum procalcitonin in the patients with local infection was higher than that in the patients with non infection, the difference was statistically significant （P 〈 0. 05）. Conclusion Serum procalcitonin levels change helps to understand the infection status of the patients with acute exacerbation of chronic obstructive pulmonary disease, and is helpful for evaluation of the prognosis.

关 键 词：慢性阻塞性肺疾病 急性加重期 感染 血清降钙素原 

分 类 号：R563.9[医药卫生—呼吸系统]