盐酸小檗碱β-环糊精聚合物微球的制备和释药性能研究  

Synthesis of berberine hydrochloride encapsulated into β-cyclodextrin polymer microspheres and its behavior of drug release

作　　者：余丽丽[1] 尤静[1] 姚琳[1] 杨黎燕[1] 王晶晶[1] 范涛[1] 邓文婷[1] 

机构地区：[1]西安医学院药学院,西安710021

出　　处：《化工新型材料》2013年第6期53-55,共3页New Chemical Materials

基　　金：陕西省教育厅科研计划项目资助(11JK0694);西安医学院博士科研启动基金(2011DOC05);陕西省教育厅产业化培育项目(08JC18)

摘　　要：以β-环糊精为单体,环氧氯丙烷为交联剂,通过反相乳液聚合法和共沉淀法制备了盐酸小檗碱β-环糊精聚合物微球(BH-β-CDPM)。多媒体显微镜验证了β-CDPM的球形结构;紫外光谱分析研究表明,通过共沉淀法制备的微球对BH的包载性能较优,BH-β-CDPM的包封率最大为69.45%;通过对BH-β-CDPM的体外释药行为研究,发现介质的pH值对其释药效果影响较大,在碱性介质(pH=9.9)中缓释性能较好,中性介质释放较快,且药物投加量越低缓释越显著。BH-β-CDPM(30∶1)在pH=2.2的介质中药物的释药动力学过程附合Higuchi和Korsmeyer-Peppas模型,可见该条件下药物的释放主要是Fikc扩散过程。B-cyclodextrin polymer microspheres（13-CDPM）were prepared using 13-cyclodextrin as monomer and epi- chlorohydrin as a crosslinking agent by inverse emulsion polymerization method and co-precipitation method. The spherical structure of B-CDPM was demonstrated by multimedia microscope. UV spectroscopy study shown that BH-I3-CDPM had excellent entrapment capacity , the encapsulation efficiency was 69. 45%. The in vitro release behavior research showed that the pH of medium was a influencing factor for the drug release process. And the release rate of drug from BH-B-CDPM was much slowly in alkaline medium than in a neutral medium. And the sustained release was more significant with a low drug dosage. The drug release process of BH-B-CDPM in the medium（pH= 2. 2）accorded with both Higuchi and Korsmeyer- Peppas model,which indicated that the drug release in this condition was a Fikc diffusion process.

关 键 词：β-环糊精聚合物微球 盐酸小檗碱 药物释放 动力学 

分 类 号：TQ460.1[化学工程—制药化工]