高频重复经颅磁刺激联合药物治疗精神分裂症阴性症状的临床疗效  

The randomized,double-blind controlled study of high-frequency repetitive transcranial magnetic stimulation in the treatment of schizophrenia patients with negative symptoms

作　　者：蒲绮霞[1] 张春萍[1] 黄雄 余国汉[1] 王丹逢[1] 黄建伟[1] 古志文[1] 江妙玲[1] 张敏玲[1] 

机构地区：[1]广州市精神病医院,510370

出　　处：《实用医学杂志》2013年第13期2133-2135,共3页The Journal of Practical Medicine

摘　　要：目的:探讨高频重复经颅磁刺激合并药物治疗对精神分裂症阴性症状的作用。方法:将64例精神分裂症患者随机分为两组,一组给予高频(10Hz)经颅磁刺激(治疗组),另一组予假经颅磁刺激(对照组),以阳性和阴性精神症状评定量表(PANSS)、蒙哥马利抑郁量表(MADRS)、卡尔加里精神分裂症抑郁量表(CDSS)为工具,评估经颅磁刺激前后患者阴性症状的变化。通过功能核磁共振成像观察患者局部脑血流量变化情况。结果:经颅磁刺激治疗2周后,治疗组阴性症状评分低于对照组,差异具有统计学意义(P<0.05);所有受试者治疗前后局部脑血流量比较差异无统计学意义,两组均未见明显不良反应。结论:高频重复经颅磁刺激合并药物治疗可改善精神分裂症阴性症状,且安全性好。Objective To investigate the effect of high-frequency repetitive transcranial magnetic stimulation （rTMS） in combined with stable dose neuroleptic treatment on the schizophrenia patients with negative symptoms. Methods Sixty-four schizophrenia patients were enrolled in this study. The patients in the active stimulated group were treated with 10 Hz high-frequency rTMS. Functional magnetic resonance imaging（fMRI） was performed before and after rTMS treatment. Results High-frequency rTMS contributed to a significant reduction of negative symptoms of patients in the active stimulated group compared with the sham control group. However, no changes in regional cerebral blood flow could be detected by fMRI in both two groups. Conclusions Beneficial effects of high-frequency rTMS on the schizophrenia patients with negative symptoms were demonstrated.

关 键 词：精神分裂症 阴性症状 高频重复经颅磁刺激 功能核磁共振成像 

分 类 号：R749.3[医药卫生—神经病学与精神病学]