淫羊藿素的合成  

Synthesis of Icaritin

作　　者：牟关敏[1] 蒲文臣[2] 周敏[2] 刘燕[2] 杨海君[1] 王淳[2] 

机构地区：[1]西南科技大学材料学院,绵阳621010 [2]中国科学院成都生物研究所,成都610041

出　　处：《有机化学》2013年第6期1298-1303,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20932007)资助项目~~

摘　　要：淫羊藿素是淫羊藿苷的苷元,具有抗骨质疏松和调节雌激素等多种生物活性.以间苯三酚为原料,经Houben-Hoesch反应、一锅法Algar-Flynn-Oyamada反应和铕促异戊烯基重排等8步反应实现了淫羊藿素的合成,总收率4.2%.中间体及最终产物的结构均通过NMR和HRMS进行了表征.Icaritin, the aglycone of icariin, has many pharmacological and biological activities, such as antiosteoporosis activ- ity and estrogen regulation. The synthesis of caritin via an eight-step strategy including Houben-Hoesch acylation, one-pot Algar-Flynn-Oyamada reaction and europium-promoted prenylation etc., from anhydrous phloroglucin is reported in this pa- per. All the compounds were characterized by NMR and HRMS spectea.

关 键 词：淫羊藿素 黄酮醇 异戊烯基 Algar-Flynn-Oyamada 

分 类 号：R284[医药卫生—中药学]