岗稔根五环三萜类化学成分的研究  

Pentacyclic Triterpenoids from the Roots of Rhodomyrtus tomentosa

作　　者：熊娟[1] 黄亚[1] 唐宇[1] 尤梅[1] 胡金锋[1] 

机构地区：[1]复旦大学药学院天然药物化学教研室,上海201203

出　　处：《有机化学》2013年第6期1304-1308,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.81273401;81202420);教育部高等学校博士学科点(博导类)基金(No.20120071110049);"博士点新教师基金"(No.20120071120049);科技部"重大新药创制"重大专项公共资源平台(No.2011ZX09307-002-01)资助项目~~

摘　　要：首次对桃金娘Rhodomyrtus tomentosa根部(岗稔根)的化学成分展开研究,从其甲醇提取物中分离得到8个五环三萜类化合物.上述化合物的结构经一维、二维核磁共振谱和质谱等波谱技术分别鉴定为:23-O-顺式-对-香豆酰基-2α,3β-二羟基齐墩果烷-12-烯-28-酸(1),23-O-反式-对-香豆酰基-2α,3β-二羟基齐墩果烷-12-烯-28-酸(2),3β-O-反式-阿魏酰基-2α,23-二羟基齐墩果烷-12-烯-28-酸(3),3β-O-反式-对-香豆酰基-2α,23-二羟基齐墩果烷-12-烯-28-酸(4),3β-O-顺式-对-香豆酰基-2α,23-二羟基齐墩果烷-12-烯-28-酸(5),山楂酸(6),阿江揽仁酸(7)和2α,3β-dihydroxytaraxer-20-en-28-oic acid(8).其中化合物1和3为新的齐墩果烷型三萜,化合物2,4～6和8为首次从该植物中分离得到.Eight pentacyclic triterpenoids were isolated from the methanol extract of the roots of Rhodomyrtus tomentosa. By application of spectroscopic methods （especially 1D-, 2D-NMR, MS）, the structures were established as 23-cis-p-coumaroyl- oxy-2a,3fl-dihydroxyolean-12-en-28-oic acid （1）, 23-trans-p-coumaroyloxy-2a,3fl-dihydroxyolean-12-en-28-oic acid （2）, 3fl- O-trans-ferulyl-2a,23-dihydroxyolean-12-en-28-oic acid （3）, 3 fl-O-trans-p-coumaroyl-2a,23-dihydroxyolean-12-en-28-oic acid （4）, 3fl-O-cis-p-coumaroyl-2a,23-dihydroxyolean-12-en-28-oic acid （5）, maslinic acid （6）, arjunolic acid （7）, and 2a,3fl-dihydroxytaraxer-20-en-28-oic acid （8）. Among them, compounds 1 and 3 were new oleanane-type triterpenoids, while compounds 2, 4~6 and 8 were isolated from this plant for the first time. This is the first report on the chemical constituents from the roots ofR. tomentosa.

关 键 词：岗稔根 桃金娘科 化学成分 五环三萜 

分 类 号：R284[医药卫生—中药学]