海南暗罗根中一个新的克罗烷型二萜  

A New Clerodane Diterpenoid from the Roots of Polyalthia laui Merr.

作　　者：李小宝[1] 宋小平[1] 陈光英[1] 韩长日[1] 陈文豪[1] 郑彩娟[1] 宋鑫明[1] 

机构地区：[1]海南师范大学化学与化工学院热带药用植物化学教育部重点实验室,海口571158

出　　处：《有机化学》2013年第6期1333-1336,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.81160391;21166009;21162009);科技部973计划前期研究专项(No.2011CB512010)资助项目~~

摘　　要：采用硅胶柱层析,制备薄层层析等色谱方法,从海南暗罗根中分离得到8个二萜类化合物,分别鉴定为polyalimide A(1),kolavenic acid(2),2-oxo-kolavenic acid(3),2-oxo-14,15-bisnor-3,11E-kolavadien-13-one(4),3,4-dihydroxyclerodan-13E-en-15-oic acid(5),longimide B(6),16-oxocleroda-3,13E-dien-15-oic acid(7),solidagonal acidmethyl ester(8).其中化合物1为新化合物,化合物5首次从番荔枝科分离得到,所有化合物首次从该植物中分离得到.化合物2和3对人肿瘤细胞SPCA-1,SGC-7901和K-562显示微弱的细胞毒性.Eight clerodane-type compounds were isolated from the roots of Polyalthia laui and purified by silica gel column chromatorgraphy and preparative thin layer chromatorgraphy （TLC）. Their structures were elucidated as polyalimide A （1）, kolavenie acid （2）, 2-oxo-kolavenic acid （3）, 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one （4）, 3,4-dihydroxyclerodan-13E- en-15-oic acid （5）, longimide B （6）, 16-oxocleroda-3,13E-dien-15-oie acid （7）, and solidagonaI acid methyl ester （8）. Com- pound 1 was a novel compound and compound 5 was isolated from this family for the first time, and all compounds were iso- lated for the first time from this plant material. Compounds 2 and 3 showed weakly inhibitory activities against SPC-A-1, SGC-7901 and K-562 human tumor cells.

关 键 词：暗罗属 海南暗罗 polyalmide A 

分 类 号：R284[医药卫生—中药学]