他克莫司血药浓度监测与合理用药分析  

Analysis of Blood Concentration Monitoring of Tacrolimus and Rational Use of Drugs

作　　者：谢华[1] 王荣[1] 武晓玉[1] 李文斌[1] 张娟红[1] 贾正平[1] 

机构地区：[1]兰州军区兰州总医院全军高原环境损伤防治重点实验室/全军临床药理基地,兰州730050

出　　处：《中国药房》2013年第26期2427-2429,共3页China Pharmacy

摘　　要：目的:通过分析服用他克莫司(FK506)患者的全血浓度监测结果,参考有效的治疗范围,为FK506血药浓度监测及临床合理用药提供参考。方法:采用回顾性分析,以我院2011年12月-2012年12月FK506血药浓度监测的977人次为研究对象,对血药浓度监测结果正常范围的治疗效果及异常监测结果进行分析。结果:977人次中,正常、低于、高于参考范围所占的比例分别为65.5%、33.2%、1.3%。血药浓度的异常可能与患者的饮食、依从性、合并用药、血容量、监测方法及个体差异有关。FK506不良反应相对少见。结论:应用FK506时应遵循个体化用药的原则,从小剂量开始,并根据患者FK506的血药浓度、肝肾功能及机体的耐受力进行综合评估,及时调整用药。OBJECTIVE： To provide reference for blood concentration monitoring of tacrolimus （FK506） and clinical use of drug by analyzing the blood concentration monitoring results of FK506 and referring to the effective range of treatment. METH-ODS： Blood concentration of FKS06 in 977 patients as research object was determined by retrospective method in our hospital dur- ing Dec. 2011- Dec. 2012. Therapeutic effect of normal range of blood concentration monitoring was analyzed as well as results of abnormal monitoring. RESULTS： Among 977 patients, blood concentration of FK605 which was equal to, lower than or higher than reference range accounted for 65.5%, 33.2% and 1.3%, respectively. Abnormal blood concentration may be related to the compliance of patient and drug dosage. The adverse drug reactions of FK506 was rarely found. CONCLUSIONS： FKS06 should fol-low the principle of individual medication, starting from small dose; based on the blood concentration of FK506, liver and kidney function and the body＇s tolerance were evaluated comprehensively to adjust medication timely.

关 键 词：他克莫司 血药浓度监测 合理用药 

分 类 号：R979.5[医药卫生—药品] R969.3[医药卫生—药学]