红花石蒜中的一个新石蒜生物碱(英文)  

A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata

作　　者：黄升殿[1,2] 张于[1] 何红平[1] 李石飞[1,2] 唐贵华[1,2] 陈铎之[1,2] 曹明明[1,2] 邸迎彤[1] 郝小江[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,昆明650201 [2]中国科学院大学,北京100049

出　　处：《中国天然药物》2013年第4期406-410,共5页

基　　金：supported by the National Natural Science Foundation of China(No.30830114);Young Academic and Technical Leader Raising Foundation of Yunnan Province to Y.-T.Di(No.2009CI072)~~

摘　　要：目的:研究红花石蒜中的石蒜生物碱。方法:采用多种层析柱分离手段,运用NMR和HR-ESI-MS等波谱技术鉴定化合物的结构。此外,生物碱110进行了流感甲型病毒的活性测试。结果:从红花石蒜中分离鉴定了1个新石蒜生物碱和9个已知的石蒜生物碱:2-methoxy-6-O-ethyloduline(1),2-methoxy-6-O-methyloduline(2),trispherine(3),8-O-demethylho-molycorine(4),homolycorine(5),9-O-demethylhomolycorine(6),oduline(7),lycorenine(8),6α-O-methyllycorenine(9)和O-ethyllycorenine(10)。结论:化合物1为新的高石蒜碱类型的石蒜生物碱,生物碱13为该植物中的主要成分,且对流感甲型病毒显示了较弱的抗病毒活性,IC50分别为2.06,0.69,2.71μgmL1,CC50分别为14.37,4.79,80.12μgmL1。AIM： To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata. METHODS： The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A. RESULTS： One new homoly- corine-type alkaloid 2α-methoxy-6-O-ethyloduline （1）, together with nine known alkaloids 2o：-methoxy-6-O-methyloduline （2）, trispherine （3）, 8-O-demethylhomolycorine （4）, homolycorine （5）, 9-O-demethylhomolycorine （6）, oduline （7）, lycorenine （8）, 6α-O-methyllycorenine （9） and O-ethyllycorenine （10） were obtained. CONCLUSION： Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg.mL^-1 and CC50 values of 14.37, 4.79, and 80.12 μg.mL^-1, respectively.

关 键 词：红花石蒜 石蒜生物碱 高石蒜碱类型 2-methoxy-6-O-methyloduline 2-methoxy-6-O-ethyloduline 

分 类 号：R284.1[医药卫生—中药学]