主动脉瓣退行性变发病机制的研究进展  

Research Progress of Pathogenesis in Degenerative Aortic Valvular Disease

作　　者：孙静[1] 王联群[1] 

机构地区：[1]天津市胸科医院心外科,天津市300051

出　　处：《中国分子心脏病学杂志》2013年第3期577-580,共4页Molecular Cardiology of China

基　　金：天津市卫生局科技基金资助项目(2010KZ60)

摘　　要：主动脉瓣退行性变导致的主动脉瓣狭窄已成为西方国家主动脉瓣置换的最常见原因,该病早期的表现为主动脉瓣硬化。即使在血流动力学没有显著阻塞的情况下,主动脉瓣退行性变造成的心血管原因死亡的风险也增加到50%。我国渐入老龄社会,可以预见将会有更多的人患主动脉瓣退行性变。主动脉瓣退行性变的发病是一个主动的过程,在其发病中有多机制的参与:血流动力学的影响、炎症、脂质沉积、细胞外的基质重构、骨化和遗传学均参与了这一过程,对此做一综述。Aortic stenosis caused by degenerative aortic valvular disease has become the most common cause of aortic valve replacement in western countries. A milder form of degenerative aortic valvular disease characterized by stiffening of aortic valve. Even in the absence of a hemodynamically significant obstruction, it is associated with a higher death risk from cardiovascular causes which is increased up to 50 percent. Gradually getting into aging society, it can be expected there will be more and more people suffering from aortic valve degeneration. Degenerative aortic valvular disease is an active process. Hemodynamics, Inflammatory infiltrate, lipid deposition, extracellular matrix remodeling, ossification and genetics are involved in this process. This article reviews that.

关 键 词：主动脉瓣 退行性变 发病机制 

分 类 号：R542.5[医药卫生—心血管疾病]