光谱法研究葫芦脲对褪黑素的分子识别作用  

Study on the Molecular Recognition of Cucurbit[n]urils from Melatonin by Spectroscopic Methods

作　　者：秦艳芳[1,2] 李军[3] 吴昊[1] 

机构地区：[1]山西师范大学化学与材料科学学院,山西临汾041004 [2]长治学院师范分院,山西长治046000 [3]晋中学院化学化工学院,山西晋中030600

出　　处：《晋中学院学报》2013年第3期44-48,共5页Journal of Jinzhong University

摘　　要：采用荧光光谱、紫外吸收光谱法研究了葫芦[5]脲、葫芦[6]脲、葫芦[7]脲分别与褪黑素的相互作用,考察了溶液的pH值、常用溶剂等对包合物的形成及荧光强度的影响.实验结果表明,褪黑素与葫芦[7]脲不发生作用,而与葫芦[5]脲和葫芦[6]脲发生相互作用,均形成物质的量比为1:1的稳定的包合物.The inclusion interaction between cucurbit [n] urils （n = 5,6,7）and melatonin was studied by UV spectroscopic and fluorimetric methods. The fluorescent intensity and the stability of the complex by pH values and common organic solvents were also investigated. The experiment results indicate that Cucurbit [5] urils and cucurbit 1-63 urils respectively form a 1：1 complex with melatonin. There is no interaction between Cucurbit [7] urils and melatonin, while there is interaction between Cucurbit [5] urils and Cucurbit 1.6] urils.

关 键 词：葫芦[n]脲 褪黑素 荧光光谱 紫外吸收光谱 包合物 

分 类 号：R917[医药卫生—药物分析学]