C-反应蛋白研究进展及热点争议  

Research progress in,hot-spots of and controversies on C-reactive protein

作　　者：白彩娟[1] 吉尚戎[1] 

机构地区：[1]兰州大学生命科学学院,兰州730000

出　　处：《兰州大学学报（自然科学版）》2013年第3期361-369,377,共10页Journal of Lanzhou University(Natural Sciences)

基　　金：国家自然科学基金项目(31270813);高等学校博士学科点专项科研基金项目(20100211110006)

摘　　要：长期以来,C-反应蛋白(CRP)作为炎症标示因子被应用于临床检测,用来表征急性炎症反应.近期大量研究表明CRP在与慢性炎症相关的心血管疾病中扮演预报因子和参与者的双重角色,而后者逐渐成为邻域内研究的热点.但是,CRP参与病理过程的机制尚未明确,研究结果还存在各种争议.流行病调查、体外效应、动物模型及免疫组化多方面的数据调研显示:除了研究方法的原因外,CRP存在不同的天然异构体形式(五聚体pCRP和单体mCRP),或许可以更为合理地解释目前研究中所存在的争议.C-reactive protein（CRP） has long been used in clinical examination as an inflammation marker for acute inflammatory responses.Recent evidences indicate that CRP also plays a dual role in development of cardiovascular diseases（CVD） that are associated with inflammation.It is a predictor of CVD and also a participant which become the hotpot in fields of research gradually.However,the underlying mechanisms by which CRP functions in the pathophysiologic process remain elusive and the results are conflicting concerning the role of CRP.In this review we discuss the properties of CRP in epidemiological investigation,invitro effects, animal models and immunohistochemistry.It can be concluded that many of the apparently contradictory actions of CRP may be attributed to different methods applied as many researchers argue,but,as we conclude here,are more likely to be due to the existence of two distinct conformations of CRP,the pentameric（pCRP） and monomeric CRP（mCRP） forms.

关 键 词：C-反应蛋白 热点争议 五聚体 单体 

分 类 号：Q71[生物学—分子生物学]