乙醇对哺乳动物心脏窦房结搏动信号传导功能的影响  

Effect of Alcohol on Pacemaking and Driving Function of Sinoatrail Node in Heart of Mammals

作　　者：程睿[1] 张季谦[1,2] 李翔[1] 高飞[1] 

机构地区：[1]安徽师范大学物理与电子信息学院,安徽芜湖241000 [2]曼彻斯特大学物理与天文学系生物物理中心

出　　处：《安徽师范大学学报（自然科学版）》2013年第3期245-248,共4页Journal of Anhui Normal University(Natural Science)

基　　金：国家自然科研基金理论物理专款项目(11047017);安徽省自然科学基金(2009KJ099B);威康信托基金Wellcome Trust(Grant No.081808/Z/06/Z);英国生物工艺生物科学研究基金BBSRC(Grant No.BBS/B1678X);U.K

摘　　要：利用哺乳动物心脏窦房结组织的二维解剖模型,模拟乙醇对窦房结搏动及信号传导功能的影响.结果发现,一方面摄入过量的乙醇会使得有生理缺陷的心脏体系出现异常搏动现象,这与临床实验现象相吻合.另一方面发现,摄入乙醇对于窦房结搏动功能有三类影响:降低L型钙离子通道的导电性能;减小神经系统分泌乙酰胆碱的能力;若过量摄入乙醇,则降低钠离子通道的导电性能.这三种情况都将直接影响窦房结组织的正常搏动功能.模拟结果有助于进一步理解因摄入乙醇而引发心脏体系异常搏动的内在机理,并为临床诊断和预防提供一定的理论参考.By using a 2D anatomical model of the intake SA node and surrounding atrial muscle of the rabbit heart, which is proposed by Zhang et al, the effect of the alcohol on pacemaking and driving function of sinoatrail node is investigated by computer simulation. The results show, on one hand, excessive intake of the alcohol can reproduce the phenomenon of abnormal rhythm in heart with physiological defect, which are consistent with the clinical phenomena, such as abnormal pacemaking or even sudden cardiac death, which is induced by reduction of the ethanol irrigation stomach experiment on rabbit. On the other hand, using this model can simulate the influence of SA node which has the ethanol intake, and the influences perform in three aspects： reduce the electric conductivity of L calcium ion channels; reduce the ability to secrete acetylcholine of the nervous system; in excess intake of ethanol, reduce the electric conductivity of sodium channel. These three factors directly affect the pacemaking and driving function of sinoatrail node. These results will help to reveal the internal mechanism of the abnormal pacemaking in complex cardiac system absorbing the ethanol and provide a theoretical guidance for the clinical diagnosis of angiocardiopathy.

关 键 词：乙醇 窦房结 仿真模拟 异常搏动 

分 类 号：Q63[生物学—生物物理学]