白血病中医证型与方药分析  

Analysis on syndrome types and prescriptions of leukemia in Chinese medicine

作　　者：司富春[1] 王振旭[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中华中医药杂志》2013年第7期1971-1976,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家回国留学人员基金优秀项目[No.国人厅发(2007)170号];河南省国际科技合作项目(No.094300510056;No.104300510019);河南省科技创新团队项目(No.2010-29);郑州市科技创新团队项目(No.10CXTD145);河南中医学院科技创新团队项目(No.2010XCXTD05)~~

摘　　要：目的:通过对1979年1月-2012年4月中国知网(CNKI)收录的中医治疗急性和慢性白血病文献中的中医证型、方剂、药物进行频数统计,分析其中医证型和方药特点,以探讨白血病中医辨证论治规律。方法:对所选文献中的证型、方剂和药物进行标准化整理、统计其出现的频数、频率和类别,分析证候要素和药物归经,并通过χ2检验比较急性与慢性白血病用药的差异。结果:急性白血病共出现28个证型,慢性白血病21个证型,其中热毒炽盛证、气血两虚证、气阴亏虚证为两者共有常见证型;证候要素分析表明火、热、瘀、痰内盛是两者常见实性病机,气、阴、血、阳亏虚是两者常见虚性病机,病位主要涉及肾、脾、肝三脏。治疗急性白血病方剂354首,其中成方220首,自拟方134首,治疗慢性白血病方剂229首,成方90首,自拟方139首,二者皆以清热剂、补益剂和理血剂最为常用。治疗急性和慢性白血病分别用药264味和246味,按功能归为42类,进一步合并为19大类,补虚、清热和活血化瘀药是二者常用药物。对所用药物种类进行χ2检验结果显示,治疗急性白血病较多用止血药和化湿药,而在慢性白血病中使用活血化瘀药较多,且差异有统计学意义(P<0.05)。结论:对急性和慢性白血病中医辨证分型、遣方用药分析的结果可为目前该病的辨证论治提供有用的参考。Objective： The literatures on the treatment of acute leukemia and chronic leukemia with Chinese medicine were collected from CNKI dated from January 1979 to April 2012. The syndrome types, prescriptions and drugs were summarized through frequency analysis so as to probe into the laws of the differentiation of syndrome and treatment of the disease in Chinese medicine. Methods： The types of syndromes, formulae and drugs were collected, standardized and made out statistics to observe the using frequency, percentage and category. Chi-square test was applied to compare the drug-using differences between acute leukemia and chronic leukemia. Results： There were 28 syndrome types in acute leukemia and 21 in chronic leukemia, and the exuberant of toxic-heat, insufficiency of qi and blood and deficiency of qi and yin were common syndromes in both leukemia. Syndrome factor analysis showed that fire, heat, blood stasis and internal phlegm was the common excessive pathogenesis in both leukemia; The deficiency of Qi, Yin, Blood and Yang was the common deficient pathogenesis; leukemia mainly involved three viscera including the spleen, kidney and liver. There were 354 prescriptions in acute leukemia and 229 in chronic leukemia collected, among which, 220 and 90 were set prescriptions, 134 and 139 were prescriptions formed by self-experience respectively in acute leukemia and chronic leukemia. The formulae of tonifying, heat-clearing and Ireating blood disorders were used more in set prescriptions in both acute leukemia and chronic leukemia. There were totally 264 and 246 kinds of drugs respectively applied in acute and chronic leukemia, classified into 42 category and further combined into 19 category in which tonic drug, removing blood stasis and heat-cleating drugs were used mostly in both leukemia. Chi-square test results showed that hemostatic and dampness-clearing drugs were more used in acute leukemia than in chronic leukemia, while activating blood circulation was more used in chronic leukemia than in acute leukemi

关 键 词：急性白血病 慢性白血病 中医 证型分析 方药分析 

分 类 号：R273[医药卫生—中西医结合]