β-环糊精及其衍生物对金丝桃素增溶及荧光增强作用  

β-Cyclodextrin and its derivatives as solubilizers and fluorescence enhancers for hypericin

作　　者：张传力[1] 郁省[1] 范健[1] 

机构地区：[1]扬州大学医学院,扬州225001

出　　处：《国际药学研究杂志》2013年第3期369-373,共5页Journal of International Pharmaceutical Research

摘　　要：目的研究β-环糊精(β-CD)及其衍生物对金丝桃素的增溶作用及荧光增强作用。方法通过测定金丝桃素在不同浓度CD衍生物中的溶解度,绘制相溶解度曲线及荧光谱图。结果随着CD浓度的增加金丝桃素的溶解度也增加,荧光强度也随着增强,金丝桃素与交联环糊精包结比为1∶2。结论β-CD及其衍生物对金丝桃素均有增溶作用,其中交联环糊精的增溶效果最为显著,且对金丝桃素具有较强的荧光增强作用。Objective To study the influence of β-cyclodextrin（β-CD） and its derivatives on solubilization and fluorescence enhancement of hypericin.Methods The phase diagram and fluorogram were obtained by determining hypericin solubility in different concentrations of β-CD and its different derivatives.Results The solubility and fluorescence intensity of hypericin were significantly enhanced by increased CD concentration and hypericin could form an inclusion compound（1∶ 2） with the cyclodextrin polymers（CDP）.Conclusion β-CD and its derivatives all have solubilization enhancing effect on hypericin with CDP showing the most significant effect.Besides,CDP have the strong fluorescence enhancement for hypericin.

关 键 词：环糊精 金丝桃素 增溶 荧光增强 

分 类 号：R285[医药卫生—中药学]