估算肾小球滤过率在健康体检中的应用及相关因素分析  

APPLICATION OF ESTIMATED GLOMERULAR FILTRATION RATE IN HEALTH EXAMINATION AND ANALYSIS OF RELEVANT FACTORS

作　　者：李宝全[1] 李贵连[1] 安翠平[1] 杨燕[1] 崔文丽[1] 周琰[1] 

机构地区：[1]河北省石家庄市中心医院检验科,河北石家庄050011

出　　处：《河北医科大学学报》2013年第6期671-673,共3页Journal of Hebei Medical University

基　　金：石家庄市科学技术研究与发展计划(091461243A)

摘　　要：目的应用血清肌酐(serum creatinine,SCr)和胱抑素C(cystatin C,Cys C)的联合方程估算肾小球滤过率(estimated glomerular filtration rate,eGFR),探讨eGFR在健康体检中的应用,并对eGFR相关因素进行分析,旨在早期发现肾功能受损。方法测量571例健康体检者SCr和Cys C浓度,应用中国eGFR课题协作组公式计算eGFR,对eGFR结果及相关因素进行分析。结果 eGFR与体质量指数、收缩压、舒张压、血丙氨酸转氨酶、谷氨酰转移酶、尿酸、胆固醇、三酰甘油、低密度脂蛋白胆固醇均呈负相关,差异有统计学意义(P<0.01);eGFR与尿液pH、高密度脂蛋白胆固醇、尿β_2微球蛋白肌酐比值均呈正相关,差异有统计学意义(P<0.01)。结论应用eGFR可早期提示肾功能异常,对其相关危险因素早期进行干预,可提高健康水平。Objective To validate the application of estimated glomerular filtration rate （eGFR） calculated with chronic kidney disease epidemiology collaboration predictive equation based on serum creatinine （SCr） and cystatin C （Cys C） in health examination and analyze its relevant factors. Methods The concentration of SCrand Cys C were measured and the eGFR was estimated with the SCr/ Cys C combinated equation of Chinese eGFR Investigation Collaborative Group in 571 healthy examination persons. The Spearman correlation analysis was performed and all data were analyzed. Results The eGFR was negatively correlated with body mass index, systolic blood pressure, diastolic blood pressure, alanine aminotransferase, γ-glutamyltransferase, uric acid, total cholesterol, triglyeeride, low density lipoprotein-cholesterol （P 〈 0. 01 ）, but was positively correlated with the pH value, high density lipoprotein-cholesterol and urine β2 microglobulin/creatinine （ P 〈 0.01 ）. Conclusion The results of this study indicated that the application of eGFR is sensitive to evaluate the renal function in health examination.

关 键 词：肾小球滤过率 创伤和损伤 肾 

分 类 号：R446[医药卫生—诊断学]