Cul-Catalyzed Multicomponent Synthesis of Aminoindolizines from Aldehydes, Amines, and Alkynes under Solvent-Free Conditions  

作　　者：Changming Pan Jianping Zou Runsheng Zeng 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Mate- rials Science of Soochow University, Suzhou, Jiangsu 215123, China

出　　处：《Chinese Journal of Chemistry》2013年第6期799-804,共6页中国化学（英文版）

摘　　要：A direct and efficient approach to 1-aminoindolizines through three-component one-pot reaction of heteroaryl aldehydes, secondary amines and terminal alkynes catalyzed by CuI under solvent-free conditions has been developed. This methodology provides a rapid access to substituted aminoindolizines with good yields （up to 97%）.A direct and efficient approach to 1-aminoindolizines through three-component one-pot reaction of heteroaryl aldehydes, secondary amines and terminal alkynes catalyzed by CuI under solvent-free conditions has been developed. This methodology provides a rapid access to substituted aminoindolizines with good yields （up to 97%）.

关 键 词：THREE-COMPONENT one-pot SOLVENT-FREE CUI heteroaryl aldehydes 

分 类 号：TQ633[化学工程—精细化工] O623.124[理学—有机化学]