Directly Regioselective Protection of Secondary Hydroxyl Group on Ribosides in Aqueous Solution  

作　　者：Ruigang Xu Fei Liu Yingju Liu Beiqing Chen Feng-Wu Liu 

机构地区：[1]School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 45000l, China

出　　处：《Chinese Journal of Chemistry》2013年第6期855-860,共6页中国化学（英文版）

摘　　要：Selective benzoylation of secondary hydroxyl on sugar moiety of various ribosides including N-ribosides, O-rihosides and 2＇-deoxy-N-riboside was investigated by using benzoyl chloride and Na2CO3 in aqueous CH3CN. The influence of the aglycone and sugar moiety on the selectivity of benzoylation was discussed as well. A most ef- ficient method for preparation of 2＇,3＇-O-dibenzoylnucleosides was developed.Selective benzoylation of secondary hydroxyl on sugar moiety of various ribosides including N-ribosides, O-rihosides and 2＇-deoxy-N-riboside was investigated by using benzoyl chloride and Na2CO3 in aqueous CH3CN. The influence of the aglycone and sugar moiety on the selectivity of benzoylation was discussed as well. A most ef- ficient method for preparation of 2＇,3＇-O-dibenzoylnucleosides was developed.

关 键 词：selective benzoylation ribosides deoxyribosides secondary hydroxyl group protection 

分 类 号：TQ655[化学工程—精细化工] O647.2[理学—物理化学]