冠心病患者外周血NT-proBNP水平与GRACE评分的相关性分析  

The correlation analysis between NT-proBNP levels in peripheral blood and GRACE score in patients with coronary heart disease

作　　者：王苏燕[1] 杨军[1] 邓彪[1] 邝孛[1] 江振涛[1] 张勇[1] 文格波[1] 

机构地区：[1]南华大学第一附属医院,湖南衡阳421001

出　　处：《山东医药》2013年第18期22-23,共2页Shandong Medical Journal

基　　金：湖南省科技厅重点项目资助项目(2009SK2010)

摘　　要：目的探讨不同危险分层的冠心病患者氮末端脑钠素原(NT-proBNP)的水平变化及其与全球急性冠状动脉事件注册(GRACE)评分的相关性。方法选择168例经过冠脉造影检查的冠心病患者,根据冠脉狭窄情况将其分为3组:正常对照组41例,稳定型心绞痛(SAP)组(SAP组)69例,急性冠脉综合征(ACS)组(ACS组)58例。用放射免疫法测定各组外周血NT-proBNP水平,并进行GRACE危险评分及分层。结果 ACS组外周血NT-proB-NP水平均高于SAP组及正常对照组(P均<0.05)。ACS组GRACE评分均高于正常对照组及SAP组(P均<0.05)。NT-proBNP水平与GRACE评分呈正相关关系(r=0.318,P<0.01)。GRACE评分高危者血NF-proBNP水平高于中、低危者(P均<0.01)。结论 ACS患者外周血NT-proBNP水平升高,并与GRACE评分有关,NT-proBNP水平越高,ACS风险越高。Objective To investigate the serum N-terminal pro-B-type natriuretic peptide（NT-proBNP） levels in patients with coronary heart disease（CHD） and its correlation with global registry of acute coronary events（GRACE） score,and then to assess the risk of CHD with the combination of them.Methods A total of 168 cases of patients who underwent coronary angiography were selected as research subjects.They were divided into three groups by coronary angiography： 41 cases of patients with non-coronary heart disease as control group;69 cases of patients with stable angina pectoris as SAP group;58 cases of patients with acute coronary syndrome as ACS group.The NT-proBNP levels of all patients were measured by radioimmunoassay.All patients were scored by GRACE system,and then layered.Results The NT-proBNP levels and GRACE score in ACS group were significantly higher than the control group and the SAP group（all P 0.05）.Then the NT-proBNP levels and GRACE score had significant positive correlation（r = 0.318,P 0.01）.The NT-proBNP levels in high risk GRACE score patients were higher than the moderated and low risk GRACE score ones（all P 0.01）.Conclusion The NT-proBNP levels in patients with acute coronary syndrome are positively correlated with GRACE risk score,and the higher the NT-proBNP levels are,the higher the risk of ACS becomes.

关 键 词：氮末端胞钠素原 全球急性冠状动脉事件注册评分 冠心病 风险评估 

分 类 号：R541.4[医药卫生—心血管疾病]