血清抗CCP抗体、抗MCV抗体与RF联合检测诊断类风湿关节炎的临床价值  

Diagnostic value of combined detection of anti-CCP,anti-MCV antibodies and RF in rheumatoid arthritis

作　　者：许军华[1] 刘树业[2] 

机构地区：[1]天津医科大学天津第一中心医院 [2]天津第三中心医院

出　　处：《山东医药》2013年第22期38-40,共3页Shandong Medical Journal

摘　　要：目的探讨抗环瓜氨酸肽(CCP)抗体、抗突变型瓜氨酸波形蛋白(MCV)抗体和类风湿因子(RF)联合检测诊断类风湿关节炎(RA)的价值。方法采用ELISA法检测101例RA患者(RA组)、55例非RA自身免疫性疾病患者(非RA组)和55例健康查体者(对照组)血清抗CCP抗体、抗MCV抗体和RF诊断RA水平,并进行比较。结果 RA组抗CCP抗体、抗MCV抗体和RF阳性率均显著高于非RA组和对照组(P均<0.01)。RA组抗CCP抗体、抗MCV抗体和RF的敏感性分别为83.2%、70.3%和79.2%,特异性分别为93.6%、94.5%和75.4%。三项指标联合检测诊断RA的特异性达99.1%,敏感性降至67.3%。结论抗CCP抗体、抗MCV抗体和RF联合检测可提高诊断RA的准确性。Objective To investigate the clinical value of combined detection of anti-cyclic citrullinated peptide （ anti- CCP） antibodies, anti-mutated eitrullinated vimentin （anti-MCV） antibodies and rheumatoid factor （RF） in rheumatoid arthritis （RA） diagnosis. Methods Anti-CCP, anti-MCV antibodies and RF were detected by ELISA in 101 RA pa- tients （RA group）, 55 patients with other rheumatic diseases （non-RA group）, and 55 healthy controls （control group）, The differences of anti-CCP, anti-MCV antibodies and RF in the three groups were compared. Results The positive ratios of anti-CCP, anti-MCV antibodies and RF were significantly higher in the RA group than those in the non-RA group and control group （ P 〈 0. O1 ）. In the RA group, the sensitivity of anti-CCP antibodies was 83.2% with 93.6% specificity, the sensitivity of anti-MCV antibodies was 70.3% and the specificity was 94.5% , the sensitivity of RF was 79.2% with 75.4% specificity. The specificity of combined detection of anti-CCP, anti-MCV antibodies and RF was increased to 99. 1%, with a lower 67.3% sensitivity. Conclusions The combined detection of anti-CCP, anti-MCV antibodies and RF could improve the diagnostic accuracy of rheumatoid arthritis （RA）.

关 键 词：类风湿关节炎 抗环瓜氨酸肽抗体 抗突变型瓜氨酸波形蛋白抗体 类风湿因子 

分 类 号：R593.22[医药卫生—内科学]