干扰素调节因子4血清水平与系统性红斑狼疮的相关性研究  

Association of serum level of interferon regulatory factor 4(IRF4) with systemic lupus erythematosus (SLE)

作　　者：刘姗姗[1] 王玮[1] 彭辉[1] 周末[1] 许可[1] 翟雨[1] 叶冬青[1] 

机构地区：[1]安徽医科大学公共卫生学院流行病与卫生统计学系,安徽合肥230032

出　　处：《中华疾病控制杂志》2013年第6期465-468,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81172764)

摘　　要：目的从血清水平探讨干扰素调节因子4(interferon regulatory factor 4,IRF4)与系统性红斑狼疮(systemic lupus erythematosus,SLE)的相关性。方法采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)分别检测90例SLE病人与90例对照血清IRF4表达水平,并结合问卷调查资料进行统计分析。结果 SLE患者与对照组,狼疮肾炎组与非肾炎组,疾病活动期与稳定期患者之间血清IRF4水平差异均无统计学意义(均有P>0.05),在SLE患者中,血清IRF4水平与疾病活动性指数评分之间也均无相关性,但血清IRF4水平在低补体(C3降低)阳性组和阴性组之间差异有统计学意义(Z=-3.14,P=0.002),其他实验室指标阳性组与阴性组血清IRF4水平差异未发现统计学意义。结论本实验从血清水平方面未发现IRF4与SLE发病存在相关性,以后研究中可以从其他方面来验证二者之间的关系,本实验也为研究SLE发病机制提供了新的思路。Objective To explore the correlation of interferon regulatory factor 4 with systemic lupus erythematosus（SLE） from the serum level.Methods Enzyme-linked immunosorbent assay（ELISA） was performed to determinate IRF4 expression level in serum of 90 SLE patients and healthy controls respectively and related statistical analysis were done combined with the questionnaire data.Results No statistically significant differences of the serum IRF4 expression level were found between SLE patients and controls,lupus nephritis group and no lupus nephritis group,active disease and inactive disease group（all P 0.05）.No significant correlation was found between the serum IRF4 expression level and disease activity index score.The level of serum IRF4 in low complement（C3 ↓） positive group and negative group was found statistical difference（Z =-3.14,P = 0.002）,other laboratory indexes in positive group and negative group did not show significant difference.Conclusions In this experiment we found no relevance between IRF4 and SLE from the serum level,maybe we could verify their relationships from other ways,and the experiment provided a new train of thought in the research of SLE pathogenesis.

关 键 词：红斑狼疮 系统性 干扰素调节因子类 

分 类 号：R593.24[医药卫生—内科学]