中国Y-STR数据库建设相关问题探讨  

Development of Chinese Forensic Y-STR DNA Database

作　　者：葛建业 严江伟[2] 谢群[3] 孙宏钰[4] 周怀谷[5] 李斌[6] 

机构地区：[1]北德州大学健康科学中心,美国德克萨斯州76107 [2]中国科学院北京基因组研究所,北京100029 [3]公安部物证鉴定中心,北京100038 [4]中山大学中山医学院法医学系,广东广州510080 [5]上海市公安局物证鉴定中心上海市现场物证重点实验室,上海200083 [6]福建省公安厅刑事技术总队,福建福州350003

出　　处：《法医学杂志》2013年第3期212-215,221,共5页Journal of Forensic Medicine

摘　　要：Y染色体是男性所特有的父系遗传染色体,Y染色体上的STR基因座已经大量应用于实际案件。本文总结了Y-STR的特性以及选择适合中国人群的Y-STR基因座所需要考虑的问题,展望了Y-STR在家系排查、亲缘搜索、来源人群推断、混合样本检验、亲缘关系鉴定等方面的应用前景,并探讨了Y-STR试剂盒研发、验证,Y-STR突变率,搜索软件等方面的问题,提出了相应的建议。Y chromosome is a male-specific paternal inherited chromosome, the STP markers on I chromosome have been widely used in forensic practices. This article summarizes the characteristics of Y-STR and some factors are considered of selecting appropriate Y-STR markers for Chinese population. The prospects of existing and potential forensic applications of Y-STR profiles are discussed including familial excluding, familial searching, crowd source deducing, mixture sample testing, and kinship identi- fying. The research, development, verification of Y-STR kit, Y-STR mutation rate, and search software are explored and some suggestions are given.

关 键 词：法医遗传学 Y染色体 综述[文献类型] 短串联重复序列 DNA数据库 

分 类 号：DF795.2[医药卫生—法医学]