恒河猴颧骨种植支抗后牵引上颌骨矫形作用的组织学研究  

Histological changes of craniofacial sutures after retractive forces with zygomatic implant anchorage to the maxilla of rhesus monkeys

作　　者：张晓蓉[1] 曾祥龙[2] 徐芸[1] 

机构地区：[1]昆明医科大学附属口腔医院正畸科,昆明云南650031 [2]北京大学口腔医学院.口腔医院正畸科,北京100081

出　　处：《上海口腔医学》2013年第3期252-259,共8页Shanghai Journal of Stomatology

基　　金：云南省科技计划项目(2007C0029R)~~

摘　　要：目的:采用颧骨种植支抗后牵引上颌骨,观察在牵引力作用下上颌骨和颧骨周围相关骨缝的组织学变化。方法:生长发育期恒河猴4只,3只用于研究(1只牵引1.5个月、2只牵引3个月),1只作为对照;HE染色和活体骨标记染色,观察上颌骨周围的颧颌缝、横腭缝、翼腭缝、额颌缝以及颧骨后部的颧额缝、颧颞缝、蝶颧缝的组织学变化。结果:上颌骨周围4条骨缝发生明显的以吸收为主的组织学反应。由于骨缝的位置和走向不同,横腭缝、额颌缝表现为骨突顶部吸收为特征的楔形交错性反应;翼腭缝表现为骨突一侧骨表面沉积、另一侧表面骨吸收的位相性反应;颧颌缝兼有2种反应。颧骨后部骨缝呈现牵张状态,观察到骨沉积增加,破骨活动较弱,同样表现出3种不同的骨缝反应。结论:颧骨种植支抗后牵引使上颌骨和颧骨周围骨缝发生了有别于生理性生长改建的明显变化,但未发现破坏性改变。上颌骨周围骨缝组织学反应以吸收为主,不同骨缝组织学反应有所差异,上颌骨因此向后移动并伴有一定的旋转。颧骨后部骨缝发生了与传统口外弓作用不同的牵张成骨反应。PURPOSE： To demonstrate the histological changes of the maxilla-facial sutures caused by retractive forces of a zygomatic implant anchorage to the maxilla of rhesus monkeys. METHODS： Four young male rhesuses were employed, 3 in the experimental group （1 was been distracted for 1.5 months and 2 for 3 months）, and 1 as control. HE staining and vital fluorescent were used to observe histological changes in the circum-maxillary sutures （i.e. zygomaticomaxillary suture, transverse palatine suture, frontomaxillary suture and pterygopalatine suture） and the posterior sutures （i.e. zygomaticotemporal suture and sphenozygomatic suture, sphenozygomatic suture） of zygoma bone caused by retractive forces of zygomatic implant to the maxilla of rhesus monkeys. RESULTS： Obvious reactions of compressive stress and bone resorption were observed around the 4 circum-maxillary sutures. There were 3 patterns of sutural reactions, indicating the direction of sutural stress influenced by sutural position and morphology. Reactions of interdigitate wedging were observed in the transverse palatine suture and frontomaxillary suture, showing a bony collision that the tip of bony process and the hollow were resorbed markedly. Phasic reactions were found in the pterygopalatine suture reaction, representing a bony sliding that one side of a bony surface was deposited while the opposite side was resorptive. Both reactions were observed in the zygomaticomaxillary suture. Tensile stresses were observed in the 3 sutures around anchoraged zygoma bone （i.e. zygomaticotemporal suture, sphenozygomatic suture and sphenozygomatic suture） with similar three-pattern reactions. CONCLUSIONS： Histologically, significant changes differing from physiological remodeling areobserved in the circum-maxillary sutures and posterior sutures of zygoma bone, but no destructive changes are fcmnd. These findings demonstrate that bone resorptions are major reactions caused in the 4 cireum-maxillary sutures. Different sutures respond slight histolog

关 键 词：颧骨种植体支抗 后牵引上颌骨 恒河猴 骨缝 组织学变化 

分 类 号：R783[医药卫生—口腔医学]