姜黄素对9月龄APPswe/PS1dE9双转基因小鼠行为学的影响  

Effect of curcumin on the ethology of APPswe/PS1dE9 transgenic mice

作　　者：樊惠[1,2] 魏鹏[1,2] 陈晓培[1,2] 冯慧利[1,2] 任映[1,2] 孙海芸[1,2] 杨金铎[1,2] 王蓬文[1,2] 

机构地区：[1]国家中医药管理局三级实验室北京中医药大学东直门医院中药药理学实验室,北京100700 [2]北京中医药大学东直门医院中医内科学教育部重点实验室和北京市重点实验室,北京100700

出　　处：《中国比较医学杂志》2013年第6期33-37,共5页Chinese Journal of Comparative Medicine

基　　金：国家自然基金面上资助项目(No.81073076);教育部高等学校创新团队(IRT0810)

摘　　要：目的应用Morris水迷宫,测试AD模型APPswe/PS1dE9双转基因小鼠定位航行及空间搜索等学习记忆和记忆保持能力,评价姜黄素对APPswe/PS1dE9双转基因小鼠认知功能的影响。方法将3月龄的APPswe/PS1dE9双转基因小鼠随机分为模型组、罗格列酮组(10 mg/kg.d)、姜黄素高(400 mg/kg.d)、中(200 mg/kg.d)、低剂量组(100 mg/kg.d),每组6只;并以同月龄遗传背景相同的C57/BL6J小鼠作为对照组。每天灌胃给药1次,连续灌胃6个月。应用Morris水迷宫进行行为学检测。结果姜黄素对APPswe/PS1dE9双转基因小鼠空间学习记忆能力障碍有改善作用,尤以姜黄素大剂量和中剂量组效果比较明显。结论姜黄素能改善APPswe/PS1dE9双转基因小鼠的认知功能。Objective To evaluate the effect of curcumin on cognitive function of APPswe/PSldE9 double transgenic mice. Methods 3-month old APPswe/PSldE9 dtg mice were randomly divided into model group, rosiglitazone group and curcumin high-, medium- and low-dose groups （n =6） , with age-matched C57BL/6J mice of the same genetic background as normal control group. Medication was given once a day by intragastric garage for 6 months. Morris water maze was used to test the spatial learning and memory ability of APPswe/PSldE9 double transgenic mice. Results Curcumin showed improvement effect on the spatial learning and memory disabilities of APPswe/PSldE9 double transgenic mice, especially in the curcumin high-dose and medium-dose groups. Conclusion Curcumin can improve learning and memory ability of APPswe/PSldE9 double transgenic mice.

关 键 词：姜黄素 APPswe/PS1dE9双转基因小鼠 MORRIS水迷宫 行为学 

分 类 号：R33[医药卫生—人体生理学]