Drebrin与认知功能障碍  

Relationship between drebrin and cognitive impairment

作　　者：马丽娜[1,2] 王蓉[1] 

机构地区：[1]首都医科大学宣武医院中心实验室,北京100053 [2]首都医科大学宣武医院综合科,北京市老年病医疗研究中心,神经变性病教育部重点实验室,北京100053

出　　处：《中国比较医学杂志》2013年第6期67-70,78,共5页Chinese Journal of Comparative Medicine

基　　金：北京市自然科学基金资助项目(7132044);首都卫生发展科研专项(首发2011-2001-02)

摘　　要：树突棘和突触的病理改变在认知功能障碍发病机制中具有十分重要的作用,研究表明大脑发育调节蛋白(development regulation brain protein,Drebrin)能够调节树突棘和突触的形态和重塑。Drebrin的减少可能通过树突棘内细胞骨架变化,使树突棘的形态结构受到影响,导致突触功能和结构的变化。但目前阿尔茨海默病(Alzheimer's disease,AD)脑内突触病理变化的具体机制及Drebrin和突触之间的关系仍不明确。探讨Drebrin与认知功能的关系及其机制,对临床上早期干预认知功能障碍、寻找AD的有效诊断治疗措施具有重要意义。The pathological changes of dendritic spines and synapses play an important role in cognitive impairment, and the developmentally regulated brain protein （drebrin） can regulate the morphology and plasticity of dendritic spines and synapses. The decrease of drebrin can affect the morphology of dendritic spines through the changes of spine cytoskeleton, and it can lead to changes in synaptic structure and function. But specific mechanisms of pathological synaptic changes in the brain and the relationship between drebrin and synapses in Alzheimer＇s disease （AI）） still remain unclear. Exploring the relationship between drebrin and cognitive function and internal mechanisms has important significance to early prevention of cognitive impairment and find effective measures for diagnosis and treatment of AD.

关 键 词：DREBRIN 树突棘 突触 可塑性 认知功能 阿尔茨海默病 

分 类 号：R33[医药卫生—人体生理学]