微小RNA-146在自身免疫性疾病和眼病中的研究进展  

Research progress of microRNA-146 in autoimmunity disease and thyroid associated ophthalmopathy

作　　者：杨文娟(综述)[1] 班胜刚(审校)[1] 何剑峰(审校)[1] 

机构地区：[1]广西医科大学第一附属医院眼科,南宁530021

出　　处：《中华实验眼科杂志》2013年第7期697-700,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：广西科学基金项目（桂科自0832132）

摘　　要：微小RNA（miRNA）是一类新的非编码小RNA，它通过与靶mRNA特异性结合，导致靶向mRNA降解或抑制其翻译过程而参与疾病的发生和发展，是天然存在的重要基因调控分子。越来越多的研究证实，miRNA异常与自身免疫性疾病的发生密切相关，miRNA-146即为其中研究较多的一个。甲状腺相关眼病（TAO）己被普遍认为是一种器官特异性自身免疫性疾病，其病因和发病机制尚未完全明了，难以做到根治。就miRNA-146在自身免疫性疾病中的研究进展进行回顾分析，并结合TAO的研究领域进行综述。MicroRNA （miRNA） is newly discovered,a class of small non-coding RNA which plays critical roles in the regulation of gene expression at the posttranscriptional level by either degrading or blocking translation of messenger RNA targets. Growing evidence that some miRNAs have crucial roles in controlling and modulating immunity,while dysregulation of miRNAs can lead to autoimmunity, and miRNA-146 seems to be a popular topic discussed much. Thyroid associated ophthalmopathy （TAO） is an organ specificity autoimmune disease which is closely associated with Graves disease. Although many clinical and experimental investigations have been done, the precise aetiology and pathogenesis of TAO remain largely unclear. Here we review the roles of miRNA-146 regulation in immune functions and in the development of autoimmunity and autoimmune disease, and outlook for the roles of miRNA-146 in the pathogenesis of TAO.

关 键 词：微小RNA-146 自身免疫性疾病 甲状腺相关眼病 发病机制 

分 类 号：R581.1[医药卫生—内分泌]