1-(2-芳氧基吡啶-3-甲酰基)-2-羧基四氢吡咯的合成研究  

The Synthetic Research of 1(2-aryloxy-3-acyl｝-2-carboxylpyrrolidine

作　　者：仝浩胜[1] 刘永鹏[1] 杨慧[1] 左双全[1] 叶茂[1] 彭龙斌[1] 龚银香[1] 

机构地区：[1]长江大学化学与环境工程学院,湖北荆州434023

出　　处：《长江大学学报（自科版）（上旬）》2013年第7期17-19,160,共3页JOURNAL OF YANGTZE UNIVERSITY (NATURAL SCIENCE EDITION) SCI ＆ ENG

基　　金：湖北省教育厅重点项目(B200612010);国家大学生创新性实验项目(101048920;201210489317)

摘　　要：利用酚与2-氯烟腈在氢化钠作碱化试剂条件下反应得到芳氧烟腈,再在氢氧化钠作用下水解、盐酸酸化得中间体芳氧基烟酸。芳氧基烟酸经酰氯化,再与碱化氨基酸作用,合成了3个未见文献报道的含取代氨基酸的芳氧烟酰胺类化合物。采用核磁共振氢谱和红外光谱表征了目标化合物的结构,探讨了目标化合物的基本理化性质,讨论了中间体芳氧基烟酸及目标化合物的合成条件。目标化合物的生物活性测试正在进行中。Three kinds of aryloxyniacinamides which were not reported before were synthesized.The structures of target compounds are identified by 1 HNMR and IR spectra.The physical and chemical properties of the target compounds are discussed,besides the synthetic conditions of aryloxylnicotinic acids and target compounds are discussed.The biological activity tests of target compounds are in progress.The principles are that three kinds of 3-cyano-2-aryloxypyridines are synthesized with the reaction of 2-chloro-3-cyanopyridine and phenol is alkalified by sodium hydride.Through the hydrolysis of 2-chloro-3-aryloxypyridine with sodium hydroxide and acidification with hydrochloric acid,aryloxylnicotinic acids are obtained.Via arylchlorination,it reacts with aminoacids alkalified by Sodium hydroxide.

关 键 词：芳氧基烟酰胺 氨基酸 除草剂 合成 

分 类 号：O626.5[理学—有机化学]