一般氮代谢调控蛋白NtrC的研究进展  

Progress on General Nitrogen Regulation Protein NtrC

作　　者：李琴[1,2] 燕永亮[2] 苏磊[3] 战嵛华[2] 张云华[1,2] 王荣富[1] 

机构地区：[1]安徽农业大学生命科学学院,合肥230036 [2]中国农业科学院生物技术研究所,北京100081 [3]中国农业大学农学与生物技术学院,北京100193

出　　处：《中国农业科技导报》2013年第3期113-122,共10页Journal of Agricultural Science and Technology

基　　金：国家自然科学基金(31170081;31101746);中国农业科学院基本科研业务费专项基金(1610392011004)资助

摘　　要：NtrBC是细菌氮代谢调控系统中双组分系统,其中NtrC是响应环境信号的转录激活蛋白,对靶基因具有转录激活作用。已有的研究表明NtrC在细菌氮源利用、生物固氮、高分子胞外聚合物合成、碳氮平衡等方面发挥了重要的调节作用。对NtrC的全局调控作用研究,是当前微生物代谢调控网络研究热点之一。综述了细菌NtrC近年来的研究进展,详细介绍了细菌NtrC的生物学功能及调控机制,以期为更好地了解微生物的环境适应性,代谢多样性和碳氮偶联作用的分子机制奠定理论基础。NtrBC is a two-component system involved in bacteria nitrogen metabolism regulation, and NtrC is a transcription activator protein in response to environmental signal and activates the transcription of target genes. The past studies have indicated that bacterial NtrC plays important roles in regulating diverse processes including nitrogenous compounds utilization, biological nitrogen fixation, the biosynthesis of biopolymer and maintenance on the carbon-nitrogen balance. Studies on NtrC＇s overall regulating function are one of the hotspot of microbe metabolic regulatory networks. This paper reviewed the research progress on NtrC in recent years, and described in detail the biological functions of bacterial NtrC, so as to better understand microbian environment adaptation, metabolic diversity, and the molecular mechanism of C-N coupling regulation.

关 键 词：NTRC 转录激活蛋白 碳氮代谢 调控机制 

分 类 号：Q936[生物学—微生物学]