颈动脉粥样硬化斑块与血清胆红素关系的研究  

Relationship between Carotid Atherosclerotic Plaques and Serum Bilirubin

作　　者：戴志刚[1] 武霞[1] 王涛[2] 武文元[2] 

机构地区：[1]内蒙古医科大学附属人民医院神经内科,呼和浩特010020 [2]内蒙古医科大学附属医院神经外科,呼和浩特010050

出　　处：《南昌大学学报（医学版）》2013年第3期36-38,共3页Journal of Nanchang University：Medical Sciences

基　　金：内蒙古自治区自然科学基金(20080404MS1126);内蒙古自治区卫生厅医疗卫生科研计划(2005077)

摘　　要：目的探讨患者颈动脉粥样硬化程度、性质与血清胆红素的关系。方法对存在颈动脉粥样硬化的65例患者进行颈动脉彩色多普勒检查,记录颈动脉粥样硬化斑块的部位、回声强度、颈总动脉分叉处内膜中层厚度及血管内径,并根据颈动脉狭窄程度分为轻、中、重及完全闭塞组。同时检测血清胆红素水平,并进行统计学分析。结果轻、中、重及完全闭塞组间接胆红素和总胆红素分别为:(11.735±2.275)、(14.860±3.677)μmol.L-1,(9.063±2.174)、(10.744±2.493)μmol.L-1,(7.772±1.823)、(8.417±3.018)μmol.L-1,(4.445±2.060)、(5.055±2.426)μmol.L-1。颈动脉狭窄越严重,间接胆红素、总胆红素值就越小,且间接胆红素、总胆红素与颈动脉狭窄程度呈负相关(r=-0.726、-0.759,P<0.05)。结论血清胆红素水平降低与颈动脉粥样硬化密切相关,血清胆红素可能在颈动脉粥样硬化的发生发展中起着重要的作用。Objective To investigate the relationship of carotid atherosclerosis to serum bilirubin and plasm a fibrinogen.Methods Color Doppler examination was performed in 65 patients with carotid atherosclerosis to record plaque position,echo intensity,intima-media thickness of the carotid bifurcation,and vessel diameter.These patients were divided into four groups according to the degree of carotid stenosis：mild,moderate,severe and complete occlusion.In addition,levels of serum bilirubin were detected and results were analyzed statistically.Results The levels of indirect and total bilirubin were,respectively,（11.735±2.275） and（14.860±3.677）μmol·L-1 in mild occlusion group,（9.063±2.174） and（10.744±2.493）μmol·L-1 in moderate occlusion group,（7.772±1.823） and（8.417±3.018）μmol·L-1 in severe occlusion group,and（4.445±2.060） and（5.055±2.426）μmol·L-1 in complete occlusion group.The degree of carotid artery stenosis was negatively correlated with the levels of indirect and total bilirubin（r=-0.726 and r=-0.759,respectively;P0.05）.Conclusion Carotid atherosclerosis is associated with the decreased serum bilirubin concentrations,which may play an important role in the occurrence and development of carotid atherosclerosis.

关 键 词：胆红素 颈动脉 动脉粥样硬化 彩色多普勒 

分 类 号：R543.12[医药卫生—心血管疾病]