阿尔茨海默病与总胆固醇、低密度脂蛋白、同型半胱氨酸的相关性研究  

作　　者：辜蕊[1] 缪礁丹[1] 周弋人[1] 刘艳[1] 沈富伟[1] 高励[1] 

机构地区：[1]成都市第三人民医院神经内科,四川成都610031

出　　处：《医学美学美容（中旬刊）》2013年第6期5-6,共2页

摘　　要：目的探讨阿尔茨海默病（Alzheimer＇s disease，AD）与总胆固醇（TC）、低密度脂蛋白（LDL-C）、同型半胱氨酸（Hcy）水平的相关性，为阿尔茨海默病的病因及防治提供依据。方法选择神经内科门诊及住院部阿尔茨海默病患者40例（AD组）及健康体检者51例（对照组），两组在年龄、性别无统计学差异，采取空腹静脉血检验TC、LDL—C、Hcy，对两组的检验结果进行比较。结果AD组的TC、LDL—C、Hcy水平均较对照组高，差异有统计学意义（P〈0．05）。结论TC、LDL-C、Hcy升高可能是AD的危险因素，为AD的防治提供了依据。Objective To explore the correlation between Alzheimer＇s disease（AD） and total cholesterol（TC）, low density lipoprotein cholesterol（LDL--C）, homocysteine（Hcy）, and provide the basis for further study on cause and prevention of AD. Methods Forty patients with AD （AD group）were chosen from inpatient an outpatient department of Neurology, fifty--one healthy controls（control group）were chosen from Physical examination department. There was no significant difference with two groups in age and sex. Then compare the fasting serum TC, LDL--C, Hcy of two groups. Results TC, LDL--C, Hcy levels of AD group were higher than the control group, the difference was statistically significant （P〈0.05）. Conclusions Elevated TC, LDL--C, Hcy may be a risk factor of AD, which provides the basis for the prevention and treatment of AD.

关 键 词：阿尔茨海默病 总胆固醇 低密度脂蛋白 同型半胱氨酸 痴呆 

分 类 号：R592[医药卫生—老年医学]