健脾补肾方对再生障碍性贫血患者外周血Th17及相关细胞因子水平的影响  

Effect of the Tonifying Sleep and Kidney Treatment Method on the Peripheral Levels of Th17 and Related Cytokine in Chronic Aplastic Anemia

作　　者：胡令彦[1] 周永明[1] 陈英坤[1] 胡明辉[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《云南中医学院学报》2013年第3期4-7,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(NO:81001510)

摘　　要：目的探讨健脾补肾方对70例慢性再生障碍性贫血(CAA)患者治疗前后的调节性T细胞及白介素-6(IL-6),白介素-17(IL-17)水平差异的影响。方法收集CAA患者70例,分为对照组和治疗组,治疗组45例分为脾肾阴虚组及脾肾阳虚组,采用ELISA法检测血浆中IL-17,IL-6的水平,流式方法检测Th17水平。统计治疗前后的各指标水平变化。结果与正常组比较,CAA患者Th17及IL-6水平高于正常(P<0.05)。经健脾补肾方治疗后,脾肾阳虚组Th17及相关细胞因子均有下降(P<0.05)。脾肾阳虚组IL-16水平下降(P<0.05)。对照组Th17水平下降(P<0.05)。结论健脾补肾方对CAA患者水平Th17及其相关细胞因子变化有调节作用。Objective To investigate the significance of the tonifying sleep and kidney treatment in those patients with chronic aplastic anemia through the peripheral levels and clinical significance of Th17 , IL-17 ,IL-6 . Methods Collect 70 patients with CAA and devided them into the treatment group and control group . The treatment group was derided into PISHENYINXU group and PISHENYANGXU group and treated them with the the tonifying sleep and kidney treatment . ELISA assay was used to determine the serum levels of IL-17, IL-6 of 70 patients with CAA and FCM was used to detect the Th17. Results The levels of Th17 and IL- 17 in CAA were higher than those in normal group （P〈0. 05）. The levels of Th17 and the related cytokines in PISHENYANGXU group and the level of IL-6 in PISHENYINXU group declined. The level of Th17 in normal group declined （P〈0. 05 ）. Conclusion The tonifying sleep and kidney treatment menthod may have effect on Th17 and the related cytokines.

关 键 词：再生障碍性贫血 白细胞介素-6 白细胞介素-17 TGF-β1 健脾补肾方 

分 类 号：R285.5[医药卫生—中药学]