云南白药膏不同基质对挥发性药效成分透皮率影响的研究  

Experimental Study of the Transdermal Rate by Yunnan White Powder of Volatile Medicinal Components in Different Matrix

作　　者：王万根[1] 陈真 宋美珍[1] 俞捷[1] 徐巧红 

机构地区：[1]云南中医学院,云南昆明650500 [2]云南白药集团股份有限公司,云南昆明650500 [3]温岭市第一人民医院,浙江温岭317500

出　　处：《云南中医学院学报》2013年第3期21-24,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：云南白药;云南中医学院中医药教育创新基金

摘　　要：目的运用气相色谱法测定云南白药橡胶膏、云南白药巴布膏和云南白药热熔胶中4种挥发性药效成分(樟脑、薄荷脑、冰片、水杨酸甲酯)的含量,在相同载药量前提下比较3种基质4种药效成分透皮效果。方法建立离体透皮吸收的模型,采用气相色谱法分别检测1,3,5,8h扩散液中4种挥发性药效成分的含量。结果在相同载药量前提下,巴布膏的透皮效果显著优于橡胶膏和热熔胶;而橡胶膏和热熔胶之间差别不大。结论云南白药巴布膏透皮效果能更好满足临床治疗需求,保证云南白药膏产品的生产质量和预期疗效。Objective To compare the three matrix transdermal effects of four medicinal ingredients （camphor,menthol, borneol and methyl salicylate） of The Yunnan Baiyao rubber cream, Bahu Plaster and hot melt adhesive by Gas Chromatography Method. Methods Establishment of the slow mouse skin penetration model,using the percutaneous absorption instrument,samples were collected to detect the content at 1,3,5,8 hour. Results Under the premise of the same drug loadlng,Yunnan Baiyao Babu Plaster were better than the rubber cream and hot melt adhesive significantly in transdermal effect;little difference between the rubber cream and hot melt adhesive. Conclusion Yunnan Baiyao Babu Plaster meet the demand for clinical treatment in transdermal effect more easily,this new type of adhesive matrix can ensure the production quality and expected efficacy of Yunnan Baiyao cream products, and explore the international market for the product in the future.

关 键 词：云南白药膏 气相色谱法 透皮扩散 离体 

分 类 号：R285[医药卫生—中药学]