司来吉兰对帕金森病小鼠运动能力的影响  

Effect of selegiline on athletic ability in Parkinson’s disease in mice

作　　者：赖道旭[1] 郭宝剑[1] 程俊辉 于沛[1] 徐立朋[1] 张在军[1] 

机构地区：[1]暨南大学新药研究所,广州510632 [2]广州喜鹊医药有限公司,广州510530

出　　处：《中南药学》2013年第6期421-424,共4页Central South Pharmacy

基　　金：科技型中小企业创新项目(No.2011J4200085);暨南大学科研培育与创新基金(No.21613331);国家重大新药创制-候选药物研究(No.2012ZX09103101-055);广东省教育厅国际科技合作项目(No.gjhz1102);广东省企业科技特派员工作站建设项目(编号:2011B090600033)

摘　　要：目的探讨司来吉兰对帕金森病小鼠运动行为的影响。方法用MPTP诱导帕金森病小鼠模型,以脑内多巴胺神经元数目和多巴胺含量为参照,通过Open field、Cat walk实验分别考察司来吉兰对帕金森模型小鼠活动量和运动步态的影响。结果司来吉兰能增加帕金森病小鼠脑内多巴胺神经元数目和多巴胺的含量,增加帕金森病小鼠运动量,提高运动速度和平衡能力。结论司来吉兰能改善帕金森病小鼠神经行为能力。Objective To verify the effect of selegiline on the neurological behaviors of Parkinson’s disease in mice.Methods The number of dopamine neurons and the content of dopamine as well as its metabolites in Parkinson’s disease mice induced by MPTP were tested.Open field and Cat walk assay were used to detect the movement of mice.Results Selegiline increased the number of dopamine neurons and the content of dopamine,and also increased the total ambulation time and improved Gait and postural patterns in mice with Parkinson’s disease.Conclusion Selegiline can improve the neurological behaviors of Parkinson’s disease in mice.

关 键 词：帕金森病 司来吉兰 神经行为学 多巴胺 酪氨酸羟化酶 

分 类 号：R965[医药卫生—药理学]