南京地区19家综合性医院鲍曼不动杆菌抗感染药物用药趋势分析  

Trends of antibacterial drugs use against Acinetobacter baumannii from 19 general hospitals in Nanjing area

作　　者：丁一[1,2] 欧宁[1,2] 曹加 戴惠珍[3] 罗璨 

机构地区：[1]南京医科大学第一附属医院药学部,江苏南京210029 [2]南京医科大学药学院,江苏南京211166 [3]江苏省医学情报研究所,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2013年第6期806-811,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：科技部科技重大专项"重大新药创制"(2011ZX09302-003-02);江苏省卫生厅临床药学研究项目资助(P200601)

摘　　要：目的:分析2007～2010年南京地区19家综合性三级和二级医院鲍曼不动杆菌(Ab)抗感染药物使用趋势,为评价临床合理用药提供依据。方法:根据限定日剂量(DDD)计算7类15种抗菌药物的用药频度,采用SPSS17.0软件对用药趋势进行线性回归分析。结果:三级医院碳青霉烯类、喹诺酮类、哌拉西林/他唑巴坦用药频度(DDDs/1 000)呈增长趋势,头孢哌酮/舒巴坦呈减少趋势;二级医院碳青霉烯类、四环素类、头孢菌素类、舒巴坦和他唑巴坦酶抑制剂用量均为增长趋势;19家医院碳青霉烯类、四环素类、哌拉西林/他唑巴坦及抗菌药物总用药频度为增长趋势。三级医院平均每半年所有抗菌药物用药频度均大于二级医院,仅环丙沙星小于二级医院。结论:19家医院每种和总碳青霉烯类、哌拉西林/他唑巴坦和总抗菌药物用药频度显著增加,需加强本地区感染控制以及抗菌药物临床合理应用。Objective：To analyze trends of the antibacterial drugs used against Acinetobacter baumannii from 2007 to 2010 in 19 general tertiary and secondary hospitals of Nanjing region so as to promote rational use age of medicines.Methods：The use of 7 classes and 15 kinds of antibacterial drugs were calculated and analyzed by the defined daily dose（DDD）.The trend of each drug＇s use age was determined with linear regression using SPSS17.0.Results：The comsumptions of carbapenem,fluoroquinolone,piperacillin/tazobactam were increased and cefoperazone/consumption was decreased in general tertiary hospitals.While the comsumptions of carbapenem,tetracycline,cephalosporin,piperacillin/tazobactam,cefoperazone/sulbactam were increased in general secondary hospitals.Total consumption of carbapenem,tetracycline,piperacillin/tazobactam were increased in 19 hospitals.Mean consumption of all antibacterial drugs in every 6 months in general tertiary hospitals was more than these in general secondary hospitals except ciprofloxacin.Conclusion：The use of carbapenem,piperacillin/tazobactam and total drugs rose a significantly in all general hospitals of Nanjing area.Strengthening the infection control and optimizing the use age of drug therapy should be necessary in clinical practice.

关 键 词：鲍曼不动杆菌抗感染药物 用药频度 趋势分析 

分 类 号：R969.3[医药卫生—药理学]