三唑醇类化合物的合成及其抑菌性能的研究  

Synthesis and Antimicrobial Properties of Triazolanol Compounds

作　　者：李靖[1] 刘幸平[1] 程康华[2] 崔爱玲[2] 翟炜[2] 燕乐乐[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210046 [2]南京林业大学化学工程学院,江苏南京210037

出　　处：《林产化学与工业》2013年第3期115-119,共5页Chemistry and Industry of Forest Products

基　　金：国家林业局林业公益性行业专项(201104032)

摘　　要：为了寻找高效的有机类木材防腐剂,探索三唑醇类化合物的构效关系。参考戊唑醇的化学结构,合成了9个1-(1H-1,2,4-三唑-1-基)-2-叔丁基-3-取代基-2-丙醇类化合物,所有化合物结构均经MS、1H NMR等确证;在目标化合物质量分数为0.5%～2%范围内,采用滤纸片法对4种常见的木材腐败菌进行抑菌活性试验。结果表明对位取代苯基的引入有利于三唑醇类化合物的抗菌活性,目标化合物对所选黑霉菌均显示了较好的抑制效果,其中化合物4f对绿色木霉、木腐菌均抑制能力与戊唑醇相当。In order to find effective organic wood preservatives, the structure-activity relationship of triazolanol compounds was ex- plored. Referencing to the chemical structure of tebuconazole, nine 1 - （ 1 H-1, 2,4Vtriazol-1 -yl） -2- （t-butyl） -3-substituted-2-pro- panol compounds were synthesized. They were characterized by MS and ：H NMR, etc. In the range of 0.5% -2% ,their antimi- crobial activity were evaluated by agar-well diffusion method for four kinds of wood spoilage bacteria. The expermental results showed that the para-substituted phenyl group is conducive to the antibacterial activity, and the target compounds have a good performance in anti-mildew. Moreover, the inhibitory effect of 4f against Trichoderma viride and wood-rotting fungi are considera- ble with tebuconazole.

关 键 词：三唑 三唑醇 合成 防腐性能 

分 类 号：TQ35[化学工程]