复方丹参饮对急性心肌缺血大鼠心肌组织转化生长因子β_1的影响  

Influence of Compound Danshen Drink on Transforming Growth Factor-β_1 of Myocardial Tissue in Rats with Acute Myocardial Ischemia

作　　者：李子玉[1] 卢国玲[1] 王鑫焱[1] 徐京育[2] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医药学报》2013年第3期90-92,共3页Acta Chinese Medicine and Pharmacology

基　　金：哈尔滨市科技创新人才研究专项基金(No.2011RFXYS068)

摘　　要：目的:探讨复方丹参饮对急性心肌缺血大鼠转化生长因子β1(TGF-β1)表达的研究。方法:将60只Wistar雄性大鼠随机分为6组:通心络组,消心痛组,复方丹参饮低、中、高剂量组,空白对照组。适应性喂养1周后连续空腹灌胃7天,建立大鼠急性心肌缺血模型。造模成功后取大鼠缺血处心肌组织,采用酶联免疫法检测各组大鼠心肌组织液中TGF-β1的含量。结果:与通心络组比较,消心痛组和复方丹参饮低、中、高剂量组心肌组织液中TGF-β1的含量均升高(P<0.05),有统计学意义;与消心痛组比较,除复方丹参饮中、高剂量组差异无统计学意义外(P>0.05),复方丹参饮低剂量组心肌组织液中TGF-β1的含量减少(P<0.05),有统计学意义。结论:复方丹参饮对大鼠缺血心肌组织具有保护功效,其机制与心肌组织液中TGF-β1含量水平升高有关。Objective：To explore the influence of compound Danshen Drink on transforming growth factor-β1 of myocardial tissue in rats with acute myocardial ischemia.Methods： Sixty Wistar male rats were randomly divided into six groups：traditional Chinese medicine control group（Tongxinluo group）,western medicine control group（isosorbide dinitrate group）,traditional Chinese medicine treatment group（Compound Danshen Drink low,medium,high-dose control group）,normal control group（distilled water）.Adaptive feeding for one week then hollow irrigation stomach for seven days continuously,set up myocardial ischemia model.After the model made successfully fromed myocardial ischemia in organization,using elisa method to determine the content of TGF-β1.Results： Compared with traditional Chinese medicine control group,the content ofs TGF-β1 in western medicine control group and traditional chinese medicine treatment group were evidently increased（P﹤0.05）,the difference was statistically significant;Compared with western medicine control group,the difference in traditional Chinese medicine medium,high-dose treatment group wasn＇t statistically significant;the content of TGF-β1 in myocardial tissue in low-dose treatment group was decreased（P﹤0.05）,and the difference was statistically significant.Conclusion： Compound Danshen Drink can protect myocardial tissue of ischemia rat model,and its mechanism is related to the increase of the content of TGF-β1 in myocardial tissue.

关 键 词：心肌缺血 复方丹参饮 转化生长因子β1(TGF-β1) 心肌组织 

分 类 号：R285.5[医药卫生—中药学]