无创呼吸机治疗慢性阻塞性肺疾病合并呼吸衰竭的临床疗效观察  

The clinical effect of non-invasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease combined with type Ⅱ respiratory failure

作　　者：陈逶[1] 

机构地区：[1]成都市第五人民医院呼吸内科,四川成都611130

出　　处：《实用医院临床杂志》2013年第4期133-135,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨无创呼吸机对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并Ⅱ型呼吸衰竭的临床疗效。方法 164例COPD合并Ⅱ型呼吸衰竭患者按数字随机分组法分为治疗组86例和对照组78例。两组均给予常规治疗,治疗组在此基础上加用BiPAP呼吸机面罩正压通气治疗。分别在治疗第1、2、4、10天比较两组患者的动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、心率(HR)、呼吸频率(RR)、血pH;比较两组住院时间、住院费用及再入院时间。结果治疗组有效率90.7%,对照组有效率82.1%,差异有统计学意义(P<0.05)。治疗第1、2、4、10天,治疗组PaO2上升,PaCO2、HR及RR均下降,与入院时及对照组比较,差异均有统计学意义(P<0.05)。治疗组较对照组住院天数明显缩短,再入院次数明显减少(P<0.05),总治疗费用无明显增多(P>0.05)。结论常规治疗基础上加用无创呼吸机治疗COPD合并Ⅱ型呼吸衰竭效果显著,值得临床推广应用。Objective To evaluate the clinical effect of non-invasive positive pressure ventilation（NIPPV）in the treatment of chronic obstructive pulmonary disease combined with type II respiratory failure. Methods One hundred and sixty-four patients were di- vided into 2 groups： control group（ n = 78 ）and treatment group （n = 86 ）. The two groups were treated with conventional therapy. However, the treatment group was treated with non-invasive breathing machine. Heart rate, breathing frequency and arterial blood gas were detected after 1,2,4 and 10 days of the treatment. Results Compared to treatment before, heart rate, breathing frequency and ar- terial blood gas were improved significantly in both groups. However, the non-invasive positive pressure ventilation plus conventional therapy showed more effective than conventional therapy alone. The time in hospital of patients with non-invasive positive pressure ven- tilation treatment was shorter than that of the control group patients. The readmission times reduced significantly（ P 〈 0.05 ）, and the to- tal cost of treatment has no significantly increased （ P 〉 0. 05 ）. Conclusions Non-invasive positive pressure ventilation has positive effects on patients with chronic obstructive pulmonary disease combined with type II respiratory failure. It is worthy of clinical application.

关 键 词：无创呼吸机 慢性阻塞性肺病 呼吸衰竭 

分 类 号：R563.3[医药卫生—呼吸系统] R563.8[医药卫生—内科学]