基于固相方法的环肽合成研究进展  

Advances in research on solid-synthesis of cyclic peptides

作　　者：陈敏东[1] 姜玲[1] 万方[1] 袁静[1] 

机构地区：[1]南京信息工程大学环境科学与工程学院,南京210044

出　　处：《南京信息工程大学学报（自然科学版）》2013年第3期193-200,共8页Journal of Nanjing University of Information Science & Technology（Natural Science Edition）

基　　金：江苏省"六大人才高峰"高层次人才项目;江苏省高校产业化推进项目(JH10-17);江苏省"青蓝工程"中青年学术带头人培养项目

摘　　要：环肽是一类肽链一端(N端)游离的α氨基与另一端(C端)游离的α羧基发生缩合脱水反应而形成的化合物,具有多方面的生物活性,在许多领域具有广阔的应用前景.固相合成是将反应物连接在固相载体上在一个反应容器中进行所有反应的合成方法,该法便于自动化操作,产率高,产物易分离.介绍了基于固相合成方法的环肽合成进展,包括环肽的合成原理、一般合成步骤以及影响成环的因素等.Cyclic peptide is obtained by the dehydration and condensation of one free N-terminus e^-amino group and another free C-terminal c^-carboxy group of the peptide, with a lot of biological activities such as anti-tumor, an- ti-HIV, antibacterial, antimalarial and so on. So, we believe the cyclic peptide will have a wide application prospect in many fields including biochemistry, materials, environmental protection and especially the medicine. In a whole chemical reaction,the reactant is connected to the solid phase and participates in a reaction vessel,which we call a solid-phase synthesis. The synthesis method is convenient for automatic operation, high in yield and easy to separate the product. In this paper,the principle, steps of the solid-phase synthesis and factors influencing the cyclization of cyclic peptide were reviewed.

关 键 词：环肽 固相合成 影响成环因素 

分 类 号：O62[理学—有机化学]