非瓣膜性心房颤动患者左心房血栓和/或自发显影危险因素分析  被引量:2

Risk factors of left atrial thrombus or spontaneous echo contrast in patients with non-valvular atrial fibrillation

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作  者:黄俊[1] 刘甜[1] 薛玉梅[1] 刘方舟[1] 梁妍[1] 邓海[1] 费洪文[1] 吴书林[1] 

机构地区:[1]广东省人民医院广东省医学科学院广东省心血管病研究所心内科,510080

出  处:《中华心律失常学杂志》2013年第3期172-175,共4页Chinese Journal of Cardiac Arrhythmias

摘  要:目的探索非瓣膜性心房颤动(房颤)患者左心房血栓(LAT)和/或自发显影(SEC)的危险因素。方法选择2007年7月至2012年12月在广东省人民医院住院的1544例非瓣膜性房颤患者,平均年龄(57.1±11.9)岁,男1046例,女498例,阵发性房颤1297例。根据食管超声心动图(TEE)结果分为两组:LAT和/或SEC组(109例)和无LAT和/或SEC组(1435例)。记录患者年龄、性别、房颤类型、发生房颤时间、合并疾病、超声心动图指标等,进行多因素Logistic回归分析确定LAT和/或SEC形成的独立危险因素。结果LAT和/或SEC组:LAT53例(3.4%),血栓均位于左心耳;SEC56例(3.6%)。Logistic回归分析显示持续性及长期持续性房颤(OR=1.7,95%CI1.1—2.4)、女性(OR=1.7,95%CI1.1—2.7)、心肌病(OR=2.8,95%CI1.3—5.7)、左心室射血分数(LVEF)≤0.40(OR:6.0,95%CI2.0~18.2)、左心房内径(LAD)≥40mm(OR=7.1,95%CI4.4~11.4)为TJAT或SEC形成的独立危险因素(P〈0.05).结论LAD≥40mm、LVEF≤0.40是LAT或SEC形成的最强独立预测因素,对预测房颤栓塞事件可能具有重要价值。Objective To examine the incidence and risk factors of left atrial thrombus(LAT) and/or spontaneous echo-contrast(SEC) in patients with non-valvular atrial fibrillation(AF). Methods The study included 1544 consecutive inpatients [ mean age ( 57.1± 11.9 ) years, 32% female, 1297 paroxysmal AF ( 84% ) with non-valvular AF who underwent transesophageal echocardiography (TEE) between July 2007 and Decem- ber 2012.According to TEE results, patients were divided into two groups :LAT/SEC group (n = 109) and non- LAT/SEC group (n= 1435 ).Logistic regression was used to analyse the potential risk factors such as age, gender,type of AF,duration of AF,echocardiography parameters. Results LAT was present in 3.4% and SEC in 3.6% of patients.All the LAT located in left atrial appendage.Binary Logistic regression analysis, independent risk factors of LAT/SEC included persistent AF and long-standing persistent AF ( OR = 1.7,95% CI 1.1 ± 2. 4) ,female (OR= 1.7,95%CI 1.1±2. 7) ,cardiomyopathy (OR=2. 8,95% CI 1.3-5.7) ,left ventrieular e- jection fraction (LVEF) ± 0. 40 ( OR = 6. 0,95% CI 2.0 ± 18. 2 ), left atrial diameter ( LAD ) I〉 40 mm ( OR = 7.1,95% CI 4. 4- 11.4). Conclusion An enlarged LAD and decreased LVEF are the strongest independent risk factors of LAT/SEC.They are may be useful in predicting embolic events in patients with nonvalvular AF.

关 键 词:心房颤动 左心房血栓 自发显影 危险因素 

分 类 号:R541[医药卫生—心血管疾病]

 

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