吉林省新生儿先天性甲状腺功能减低症筛查结果分析  

Analysis on screening results of newborn congential hypothyroidism in Jilin province

作　　者：张雯艳[1] 万立新[1] 郝鹏楷 刘颖[1] 赵迅[1] 郭杰[2] 

机构地区：[1]吉林省妇幼保健院,长春130061 [2]吉林大学第二医院

出　　处：《中国地方病防治》2013年第3期228-229,共2页Chinese Journal of Control of Endemic Diseases

基　　金：吉林省卫生厅基金(2012Z047)

摘　　要：目的分析吉林省新生儿先天性甲状腺功能减低症(CH)的筛查情况,探讨新生儿疾病筛查在出生缺陷干预中的重要作用。方法新生儿出生72 h后,并充分哺乳,采集足跟血滴于专用滤纸上,测定血片中促甲状腺激素(TSH)的浓度。确诊使用化学发光法检测患儿血清中的游离T3(FT3)、游离T4(FT4)以及TSH。结果 2007年4月～2012年12月,共筛查新生儿634 290例,筛查率为81.85%,筛查率呈逐年上升趋势。检出先天性甲状腺功能减低症患儿175例,发病率为1/3625。结论吉林省新生儿先天性甲状腺功能低下症的发病率与北方其他城市相近,低于全国平均水平。新生儿疾病筛查是防止智力低下,提高出生人口素质的一项重要措施。Objective To analyze the screening results of congential hypothyroidism in Jilin province,understand the prevalence of congential hypothyroidism.Methods All the neonates born in Jilin province from 2007 to 2012 were selected as study objects,the foot blood samples were obtained at 72 hours after birth and sufficient breast feeding to detect the content of TSH,the cases with positive results were recalled,and their serum samples were reexamined.Result 634 290 neonates were screened,175 neonates were found with congential hypothyroidism,the prevalence was 1 /3625.Conclusion Neonatal screening was an effective measure for early diagnosis of congential hypothyroidism,which was also the key to prevent hypophrenia and physical development retardation.

关 键 词：甲状腺功能减低症(CH) 新生儿筛查 发病率 

分 类 号：R581.2[医药卫生—内分泌]